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Avery’s Diseases of the Newborn, 11th Edition

ISBN: 9780323828239
ISBN: 9780323828239
Εκδόσεις:
Διαστάσεις 28 × 22 cm
Μορφή

Έντυπο

Εκδόσεις

Ημ. Έκδοσης

2023/06

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1488

Έκδοση

11η έκδοση

Κύριος Συγγραφέας

158,00€(Περιλαμβάνεται ΦΠΑ 6%)

Άμεσα Διαθέσιμο

Περιγραφή

Completely revised and updated, Avery’s Diseases of the Newborn, 11th Edition, remains your #1 choice for clinically focused, cutting-edge guidance on the evaluation, diagnosis, and treatment of diseases of the newborn. Drs. Christine A. Gleason, Taylor Sawyer, and a team of expert contributing authors provide comprehensive, up-to-date coverage of every key disease and condition affecting newborns, keeping you current in this fast-changing field. You’ll find the specific strategies you need to confidently provide care for this unique patient population, in a full-color, easy-to-use single volume that focuses on key areas of practice.
Key Features
  • Reflects the latest developments on all aspects of newborn evaluation and management, featuring new content, new chapters, new contributors, and fresh perspectives from a new co-editor.
  • Brings you the latest on current topics such as perinatal/neonatal COVID-19, genomics and precision medicine, acute and chronic neonatal respiratory disorders, brain injury and neuroprotection, necrotizing enterocolitis, probiotics, palliative care, prenatal drug exposure, retinopathy of prematurity, and more.
  • Provides clinically relevant, practical guidance in concise, focused chapters that include summary boxes, suggested readings, and more than 500 full-color illustrations, micrographs, and photographs.
  • Contains the 2020 American Academy of Pediatrics and American Heart Association neonatal resuscitation guidelines and the 2022 American Academy of Pediatrics guidelines on the management of hyperbilirubinemia.
  • Serves as a reliable quick reference for clinical questions and an excellent resource for board review.
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Author Information
Edited by Christine A. Gleason, MD, Academic Neonatologist and Professor Emeritus of Pediatrics, University of Washington and Seattle Children’s Hospital, Seattle, Washington

Περιεχόμενα

  • Instructions for Online Access
  • Cover image
  • Title page
  • Table of Contents
  • Any screen, Any time, Anywhere
  • Copyright
  • Dedication
  • Contributors
  • Preface
  • The History of Diseases of the Newborn
  • What’s New and Improved About This Edition?
  • Do We Still Need Textbooks?
  • Acknowledgments and Gratitude
  • Part I: Overview
  • 1. Neonatal and Perinatal Epidemiology
  • Abstract
  • Introduction—Epidemiologic Approaches to the Perinatal and Neonatal Period
  • Health Disorders of Pregnancy and the Perinatal Period
  • Factors Affecting Perinatal Health
  • Epidemiologic Study Designs in the Perinatal Period
  • Summary and Conclusions
  • Acknowledgments
  • References
  • References
  • Suggested Readings
  • 2. Ethics, Data, and Policy in Newborn Intensive Care
  • Abstract
  • Background
  • Getting Data
  • Getting Data that Matters
  • Policy Implications of Limited Data
  • Implications of Increasingly Available Data
  • Summary
  • Acknowledgment
  • References
  • References
  • Suggested Readings
  • Part II: Fetal Growth and Development
  • 3. Development, Function, and Pathology of the Placenta
  • Abstract
  • Development of the Placenta
  • Placental Functions
  • Regulation of Placental Function
  • References
  • Suggested Readings
  • References
  • 4. Abnormalities of Fetal Growth
  • Abstract
  • Definitions
  • Patterns of Altered Growth
  • Fetal Causes of Growth Restriction
  • Placental Causes of Growth Restriction
  • Maternal Causes of Growth Restriction
  • Smoking
  • Short-Term Outcomes
  • Developmental Outcomes: Early Childhood
  • Long-Term Consequences: The Developmental Origins of Adult Disease
  • Epidemiologic Challenges
  • Size at Birth Cannot Be Used as a Proxy for Fetal Growth
  • Genetics versus Environment
  • Cellular Mechanisms
  • Molecular Mechanisms: Epigenetics
  • Macrosomia
  • Summary
  • References
  • Suggested Readings
  • References
  • 5. Multiple Gestations and Assisted Reproductive Technology
  • Abstract
  • Epidemiology of Multiples
  • Diagnosing Zygosity and Chorionicity
  • The Effect of Chorionicity
  • Increase in Monozygotic Twins With Assisted Reproductive Technology
  • Neonatal Complications Associated With Multiples
  • Fetal Complications
  • Maternal Complications
  • Psychosocial Factors
  • Cost
  • Decreasing the Risk of Multiples
  • Multifetal Pregnancy Reduction
  • Summary
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 6. Prematurity and Stillbirth: Causes and Prevention
  • Abstract
  • Preterm Birth and Stillbirth: Burden in the United States and Global Estimates
  • Pathophysiology of Preterm Birth and Stillbirth
  • Demographic Factors and Disparities
  • Environmental Factors
  • Nutrition and Maternal Body Weight
  • Infection and Microbiota
  • SARS-CoV-2 Infection in Pregnancy
  • Genetic Factors
  • Placental and Pregnancy Factors
  • Prevention of Preterm Birth
  • Summary
  • References
  • Suggested Readings
  • References
  • 7. Nonimmune Hydrops
  • Abstract
  • Incidence
  • Etiology
  • Pathophysiology
  • Derangements in Fluid Homeostasis
  • Neonatal Evaluation
  • Intensive Care of the Infant With Hydrops Fetalis
  • Clinical Course and Outcome
  • References
  • Suggested Readings
  • References
  • Part III: Maternal Conditions Affecting Pregnancy Outcomes
  • 8. Maternal Diabetes
  • Abstract
  • Types of Diabetes
  • Association Between Perinatal Outcomes and Periconception Glycemic Control
  • Fetal Growth and Macrosomia
  • Maternal Preeclampsia
  • Obstetric Management of Diabetes in Pregnancy
  • Neonatal Considerations
  • References
  • Suggested Readings
  • References
  • 9. Maternal Medical Disorders of Fetal Significance
  • Abstract
  • General Principles in the Diagnosis and Management of Medical Complications During Pregnancy
  • Autoimmune Disorders
  • Cardiovascular Disease
  • Renal Disease
  • Cancer
  • Maternal Seizure Disorders
  • Perinatal Mood and Anxiety Disorders
  • References
  • Suggested Readings
  • 10. Hypertensive Complications of Pregnancy
  • Abstract
  • Classification of Hypertensive Disorders of Pregnancy
  • Chronic Hypertension
  • Gestational Hypertension
  • Preeclampsia-Eclampsia
  • Eclampsia
  • References
  • Suggested Readings
  • References
  • 11. Intrauterine Drug Exposure: Fetal and Postnatal Effects
  • Abstract
  • Introduction
  • Epidemiology of Perinatal Substance Exposure
  • Perinatal Exposure to Specific Substances
  • Screening Pregnant Persons for Substance Use Disorder
  • Medication-Assisted Treatment for Opioid Use Disorder During Pregnancy
  • Neonatal Management After Gestational Substance Exposure
  • Conclusions
  • References
  • Suggested Readings
  • References
  • Part IV: Labor and Delivery
  • 12. Assessment of Fetal Well-Being
  • Abstract
  • General Principles
  • Fetal Assessment in Low-Risk Pregnancies
  • Fetal Assessment in High-Risk Pregnancies
  • Summary
  • References
  • Suggested Readings
  • References
  • 13. Complicated Deliveries
  • Abstract
  • Overview
  • Vaginal Delivery
  • Cesarean Section
  • Operative Vaginal Delivery: Obstetric Forceps and Vacuum Extraction
  • Shoulder Dystocia
  • Vaginal Breech Delivery
  • Multifetal Delivery
  • Vaginal Birth After Cesarean: Neonatal Concerns
  • References
  • Suggested Readings
  • References
  • 14. Obstetric Analgesia and Anesthesia
  • Abstract
  • Anatomy of Labor Pain
  • Changes in Maternal Physiology and the Implications
  • Analgesic Options for Labor and Vaginal Delivery
  • Neuraxial Opioids
  • Summary
  • References
  • Suggested Readings
  • References
  • 15. Perinatal Transition and Newborn Resuscitation
  • Abstract
  • Transition from Fetal to Extrauterine Life
  • Birth Environment and Preparation for the Delivery
  • Newborn Resuscitation
  • Apgar Score
  • Delivery Room Monitoring
  • Specific Problems Encountered During Resuscitation
  • Limits of Viability
  • Post-resuscitation Care
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • Part V: Essentials of Newborn Care
  • 16. Care of the Newborn
  • Abstract
  • Introduction
  • Initial Newborn Evaluation
  • Routine Management of the Newborn
  • Common Problems in Newborn Care
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • 17. Temperature Regulation
  • Abstract
  • Mechanisms of Heat Loss
  • Mechanisms of Thermoregulation
  • Thermal Management Strategies
  • Warming Infants
  • Weaning to an Open Crib
  • Additional Considerations
  • References
  • Suggested Readings
  • References
  • 18. Newborn Screening
  • Abstract
  • Screening Procedure
  • Disorders Screened
  • Specific Issues in Newborn Screening
  • The Future
  • References
  • Suggested Reading
  • References
  • Part VI: High-Risk Newborn Care
  • 19. Neonatal Transport
  • Abstract
  • Regionalization of Neonatal Care, Care in the Community, and Transfer Agreements
  • Transport Communication
  • Medical Supervision
  • Mode of Transport
  • Transport Personnel, Education, and Team Composition
  • Quality Improvement
  • Transport Administration
  • Transport Team Safety Training and Protocols
  • Family-Centered Care
  • Medical Legal Issues
  • Patient Care During Transport
  • Future Directions
  • References
  • Suggested Readings
  • References
  • 20. Fluid, Electrolyte, and Acid-Base Balance
  • Abstract
  • Fluid and Electrolyte Balance
  • Acid-Base Balance
  • References
  • Suggested Readings
  • References
  • 21. Neonatal Pharmacology
  • Abstract
  • Principles of Neonatal Therapeutics
  • Pharmacogenetics and Pharmacogenomics
  • Pharmacokinetic Principles
  • Clinical Applications of Pharmacokinetics
  • Drug Elimination in Breast Milk
  • Neonatal Drug Development Remains an Obvious and Shared Need
  • Summary
  • References
  • Suggested Readings
  • References
  • 22. Neonatal Pain and Stress
  • Abstract
  • Background
  • Taxonomy
  • Ontogeny and Development of Pain and Stress Responses
  • Recognizing and Treating Pain
  • Long-Term Consequences of Neonatal Pain and Stress
  • Clinical Pain and Stress Management Strategies
  • Pharmacologic Analgesia
  • Nonpharmacologic Analgesia
  • Summary
  • References
  • Suggested Readings
  • References
  • 23. Palliative Care
  • Abstract
  • What is Palliative Care?
  • Paradigms of Palliative Care
  • Scope of the Problem
  • Which Patients Benefit from Neonatal-Perinatal Palliative Care?
  • Timing of the News
  • Ethical Concerns
  • Barriers to Palliative Care in the Neonatal Intensive Care Unit
  • Training in Neonatal–Perinatal Palliative Care
  • Research Opportunities/Future Directions
  • References
  • Suggested Readings
  • References
  • 24. Risk Assessment and Neurodevelopmental Outcomes
  • Abstract
  • Outcome Assessment in High-Risk Infants
  • Outcomes of Preterm Infants Across the Life Spectrum
  • Risk Factors for Adverse Outcomes in Preterm Infants
  • Other Infants at High Risk for Adverse Outcomes
  • Postdischarge Management of the High-Risk Infant
  • References
  • Suggested Readings
  • References
  • Part VII: Genetics
  • 25. The Human Genome and Neonatal Care
  • Abstract
  • The Human Genome Project and the Big Picture of Genomic Medicine
  • The Genome and Genomics
  • Mitochondrial Deoxyribonucleic Acid
  • Variations in the Human Genome
  • Variant Counts in Individuals
  • Linking Genes and Diseases
  • Clinical Application of Next-Generation Sequencing
  • Incidental Findings
  • Genomics of Common Complex Diseases Associated With Prematurity
  • Retinopathy of Prematurity
  • Necrotizing Enterocolitis
  • Intraventricular Hemorrhage
  • Bronchopulmonary Dysplasia
  • Conclusion
  • References
  • Suggested Readings
  • References
  • 26. Prenatal Diagnosis and Counseling
  • Abstract
  • Background
  • Invasive Prenatal Diagnostic Procedures
  • Percutaneous Umbilical Cord Blood Sampling
  • Genetic Testing of the Fetus
  • Noninvasive Prenatal Screening
  • Prenatal Fetal Imaging
  • Preimplantation Genetic Diagnosis/Screening
  • Building a Prenatal Diagnosis Center
  • A Practical Guide to Prenatal Counseling
  • The Role of a Neonatologist in Prenatal Diagnosis Clinic
  • Summary
  • References
  • Suggested Readings
  • References
  • 27. The Dysmorphic Infant
  • Abstract
  • When and Why to Consider a Genetic Evaluation
  • Patterns of Anomalies
  • Genetics Evaluation
  • Specialized Clinical Evaluations
  • Literature Review
  • Specialized Laboratory Tests
  • Diagnosis
  • Summary
  • Suggested Online Resources
  • References
  • Suggested Readings
  • References
  • 28. Chromosome Disorders
  • Abstract
  • Human Karyotype
  • Trisomies
  • Deletion Syndromes
  • Segmental Duplications and Microdeletion/Microduplication Syndromes
  • Additional Microdeletion and Microduplication Syndromes
  • Disorders of Imprinted Chromosomes
  • Future Directions: Characterization of Structural Variation by Genome Sequencing
  • References
  • Suggested Readings
  • References
  • Part VIII: Metabolic Disorders of the Newborn
  • 29. Inborn Errors of Carbohydrate, Ammonia, Amino Acid, and Organic Acid Metabolism
  • Abstract
  • Carbohydrate Metabolism Disorders
  • Urea Cycle Disorders
  • Amino Acid Metabolism Disorders
  • Organic Acidemias
  • Fatty Acid Oxidation Disorders
  • Ketone Metabolism Disorders
  • Mitochondrial Disorders
  • References
  • Suggested Readings
  • References
  • 30. Lysosomal Storage Disorders Presenting in the Neonate
  • Abstract
  • Introduction
  • References
  • Suggested Readings
  • References
  • 31. Congenital Disorders of Glycosylation, Peroxisomal Disorders, and Smith-Lemli-Opitz Syndrome
  • Abstract
  • Congenital Disorders of Glycosylation
  • Peroxisomal Disorders
  • Smith-Lemli-Opitz Syndrome
  • References
  • Suggested Readings
  • References
  • Part IX: Immunology and Infections
  • 32. Immunology of the Fetus and Newborn
  • Abstract
  • Maternal and Placental Immunology
  • Developmental Fetal–Neonatal Immunology
  • Specific Immunologic Deficiencies of the Newborn
  • Implications of Studies of Immune Ontogeny for Enhancing Neonatal Immunization
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • 33. Neonatal Bacterial Sepsis and Meningitis
  • Abstract
  • Early-Onset Neonatal Bacterial Infections
  • Clinical Signs of Early-Onset Bacterial Infections
  • Evaluation of Early-Onset Bacterial Infections
  • Late-Onset Neonatal Bacterial Infections
  • Neonatal Bacterial Meningitis
  • References
  • Suggested Readings
  • References
  • 34. Viral Infections of the Fetus and Newborn
  • Abstract
  • Introduction
  • General Diagnostic Concepts
  • Cytomegalovirus
  • Rubella
  • Human Parvovirus B19
  • Zika Virus
  • Lymphocytic Choriomeningitis Virus
  • Herpes Simplex Viruses
  • Varicella-Zoster Virus
  • Human Immunodeficiency Virus
  • Hepatitis Viruses
  • Hepatitis B Virus
  • Hepatitis C Virus
  • Enteroviruses and Parechoviruses
  • Respiratory Viruses
  • Respiratory Syncytial Virus
  • Influenza
  • Adenoviruses
  • Gastroenteritis Viruses
  • Human Herpesviruses 6, 7, and 8
  • Epstein-Barr Virus
  • References
  • Suggested Readings
  • References
  • 35. Congenital Toxoplasmosis, Syphilis, Malaria, and Tuberculosis
  • Abstract
  • Congenital Toxoplasmosis
  • Congenital Syphilis
  • Congenital Malaria
  • Congenital Tuberculosis
  • References
  • Suggested Readings
  • References
  • 36. Fungal Infections in the Neonatal Intensive Care Unit
  • Abstract
  • Epidemiology
  • Pathophysiology
  • Infections Caused by Candida Species
  • Antifungal Therapy for Systemic Infection
  • Antifungal Prophylaxis
  • Infections Ascribable to Other Fungi
  • Miscellaneous Fungal Infections
  • References
  • Suggested Readings
  • References
  • 37. Healthcare-Associated Infections
  • Abstract
  • Defining Neonatal Healthcare-Associated Infection
  • Diagnosing Neonatal Healthcare-Associated Infection
  • Healthcare-Associated Infection Surveillance and Data Sources
  • Epidemiology of Healthcare-Associated Infection
  • Healthcare-Associated Infection: Distribution by Pathogen
  • Prevention of Healthcare-Associated Infection
  • Antibiotic and Adjunctive Therapies
  • Adverse Outcomes Related to Healthcare-Associated Infection
  • References
  • Suggested Readings
  • References
  • Part X: Respiratory System
  • 38. Lung Development
  • Abstract
  • Key Events in Lung Development
  • Mechanisms of Lung Development
  • Molecular Basis for Lung Development
  • Novel Concepts in Lung Development
  • References
  • Suggested Readings
  • References
  • 39. Neonatal Pulmonary Physiology
  • Abstract
  • Lung Volumes and Lung Mechanics
  • Respiratory System Compliance
  • Airway Resistance
  • Inertance
  • Dynamic Interaction
  • Work of Breathing
  • Time Constants
  • Measurements of Respiratory System Mechanics
  • Pulmonary Gas Exchange
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 40. Neonatal Respiratory Therapy
  • Abstract
  • Respiratory Support
  • Invasive Mechanical Ventilation
  • Inspired Gas Conditioning
  • Other Respiratory Gases
  • Extracorporeal Membrane Oxygenation
  • Types of Extracorporeal Membrane Oxygenation
  • Liquid Ventilation
  • Monitoring Respiratory Status
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 41. Control of Breathing
  • Abstract
  • Animal Models of Control of Breathing
  • Respiratory Muscles
  • Brainstem Rhythmogenesis
  • Neurochemical Control of Respiration
  • Genetic Mutations Affecting Respiratory Control
  • Bronchopulmonary Reflexes That Modulate the Central Respiratory Network
  • Maturation of CO2/H+ Sensitivity of Central Chemoreceptors
  • Maturation of O2 Sensitivity of Peripheral Arterial Chemoreceptors
  • Hypoxic Ventilatory Depression: Consequences for the Neonate
  • Effect of Sleep State on Breathing
  • Apnea of Prematurity
  • Therapeutic Approaches
  • References
  • Suggested Readings
  • References
  • 42. Acute Neonatal Respiratory Disorders
  • Abstract
  • Evaluation of the Newborn With Hypoxemia/Respiratory Distress
  • History
  • Physical Examination
  • Response to Supplemental Oxygen
  • Interpretation of Pulse Oximetry Measurements
  • Laboratory and Radiologic Evaluation
  • Echocardiography
  • Persistent Pulmonary Hypertension of the Newborn
  • Specific Pulmonary Conditions Causing Respiratory Distress in the Newborn
  • Respiratory Distress Syndrome
  • Risk Factors
  • Pathophysiology
  • Surfactant Physiology
  • Clinical Signs
  • Laboratory Features
  • Radiographic Features
  • Treatment
  • Exogenous Surfactant
  • Pulmonary Hemorrhage
  • Pulmonary Hypoplasia
  • Pneumonia
  • Transient Tachypnea of the Newborn
  • Congenital Diaphragmatic Hernia
  • Surfactant Protein Deficiency
  • Alveolar Capillary Dysplasia/Misalignment of Pulmonary Veins
  • Pulmonary Interstitial Glycogenosis
  • Summary
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 43. Chronic Neonatal Respiratory Disorders
  • Abstract
  • Key Points
  • Introduction
  • Epidemiology of Bronchopulmonary Dysplasia and the Vulnerable Preterm Lung
  • Pharmacological Prevention of Bronchopulmonary Dysplasia
  • Persistent Respiratory Morbidity in Former Preterm Newborns
  • Wheeze, Asthma, and Lung Function in Former Preterm Newborns
  • Conclusions
  • References
  • Suggested Readings
  • References
  • 44. Anatomic Disorders of the Chest and Airways
  • Abstract
  • Anomalies of the Airways
  • Disorders of the Mediastinum
  • Disorders of the Chest Wall
  • Disorders of the Pleural Cavity
  • Congenital Thoracic Masses and Cysts
  • Disorders of the Diaphragm
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • Part XI: Cardiovascular System
  • 45. Developmental Biology of the Heart
  • Abstract
  • Overview of Cardiac Developmental Anatomy
  • Cell Types Within the Heart and Their Origins
  • Gastrulation and the Cardiac Crescent
  • Looping and Laterality of the Heart Tube
  • Ventricular Inlet Septation: Endocardial Cushions
  • Ventricular Outflow Tract Septation: Endocardial Cushions and Neural Crest
  • Separation of Aorta and Pulmonary Artery
  • Cardiac Valve Formation
  • Development of the Ventricles and Ventricular Septum
  • Development of the Atria and Atrial Septum
  • Systemic and Pulmonary Vein Development
  • Aortic Arch Development
  • Coronary Arteries
  • Conduction System
  • Conclusion
  • References
  • Suggested Readings
  • References
  • 46. Cardiovascular Compromise in the Newborn Infant
  • Abstract
  • Principles of Developmental Cardiovascular Physiology and Pathophysiology, Phases, and Etiology of Neonatal Shock
  • Clinical Presentations of Shock in Neonates Associated With Multiple Etiologic Factors
  • Diagnosis of Circulatory Compromise
  • Treatment of Neonatal Shock
  • Extracorporeal Membrane Oxygenation (ECMO) for Circulatory Support
  • General Supportive Measures
  • References
  • Suggested Readings
  • References
  • 47. Persistent Pulmonary Hypertension
  • Abstract
  • Introduction
  • Pathophysiology
  • Risk Factors
  • Abnormal Pulmonary Vasoregulation in PPHN
  • Disorders Associated With Pulmonary Hypertension at Birth
  • Clinical Evaluation and Diagnosis
  • General Management
  • Oxygen
  • Inhaled Nitric Oxide
  • Other Therapeutic Agents
  • Outcomes
  • Summary
  • References
  • Suggested Readings
  • References
  • 48. Patent Ductus Arteriosus in the Preterm Infant
  • Abstract
  • Introduction
  • Incidence (Table 48.1)
  • Hemodynamic and Pulmonary Alterations
  • Treatment
  • References
  • Selected Readings
  • References
  • 49. Perinatal Arrhythmias
  • Abstract
  • Conduction System of the Human Heart
  • Neonatal ArrhythmiasAbnormalities in Cardiac Conduction
  • Abnormalities in Cardiac Rhythm
  • Tachyarrhythmias
  • Management Considerations for Neonatal Tachyarrhythmias
  • Bradyarrhythmias
  • Fetal Arrhythmias
  • Benign Arrhythmias
  • Fetal Tachycardias
  • Fetal Bradycardia
  • References
  • Suggested Readings
  • References
  • 50. Congenital Heart Disease
  • Abstract
  • General Considerations
  • Murmurs in the Newborn—Congenital Cardiac Lesions
  • Cyanosis in the Newborn
  • Lesions That Present Primarily With Heart Failure
  • Anomalous Origin of the Left Coronary Artery From the Pulmonary Artery
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • 51. Long-Term Neurologic Outcomes in Children With Congenital Heart Disease
  • Abstract
  • Structural and Developmental Abnormalities of the Brain in Congenital Heart Disease
  • Acquired Brain Injury With Congenital Heart Disease: Characteristics and Risk Factors
  • Conclusion
  • References
  • Suggested Readings
  • References
  • Part XII: Neurologic System
  • 52. Central Nervous System Development
  • Abstract
  • Neuronal Production and Migration
  • Programmed Neuronal Death
  • Organization of the Central Nervous System
  • Glial Proliferation, Differentiation, and Myelination
  • The Environment and Epigenetics
  • References
  • Suggested Readings
  • References
  • 53. Congenital Malformations of the Central Nervous System
  • Abstract
  • Prosencephalic Cleavage and Related Events
  • Disorders of Structures Derived From the Prosencephalon
  • Cortical Defects in Size and Organization
  • Cortical Defects in Proliferation and Neuronal Survival
  • Cortical Defects in Migration
  • Malformations of Structures in the Posterior Fossa
  • Malformations With Major Cerebellar Involvement
  • Malformations With Both Cerebellar and Brainstem Involvement
  • Malformations With Brainstem Involvement
  • Neural Tube Defects and Spinal Cord Dysraphisms
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 54. Brain Injury in the Preterm Infant
  • Abstract
  • General Principles of Preterm Brain Injury
  • Intraventricular and Periventricular Hemorrhage
  • White Matter Injury
  • Preterm Cerebral Gray Matter Injury
  • Summary
  • References
  • Suggested Readings
  • References
  • 55. Neonatal Encephalopathy
  • Abstract
  • Neonatal Encephalopathy
  • Hypoxic-Ischemic Encephalopathy
  • Other Causes of Neonatal Encephalopathy
  • Metabolic Causes of Neonatal Encephalopathy
  • Genetic Causes of Neonatal Encephalopathy
  • Central Nervous System Infections and Neonatal Encephalopathy
  • References
  • Suggested Readings
  • References
  • 56. Neonatal Neurovascular Disorders
  • Perinatal Stroke
  • Sinus Venous Thrombosis
  • Subdural and Subarachnoid Hemorrhages
  • Vascular Malformations
  • Vein of Galen Malformation
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 57. Neonatal Neuromuscular Disorders
  • Abstract
  • Neonatal Neuromuscular Disorders
  • Primary Muscle Disorders
  • Congenital Muscular Dystrophies
  • LAMA2-Related Congenital Muscular Dystrophy (Merosin-Deficient Congenital Muscular Dystrophies; MDC1A)
  • Congenital Myopathies
  • Congenital Myotonic Dystrophy
  • Metabolic Myopathies
  • Motor Neuron Disorders
  • Neonatal Neuromuscular Junction Disorders
  • Congenital Myasthenic Syndromes
  • Peripheral Neuropathies
  • Approach to the Hypotonic Newborn
  • References
  • Suggested Readings
  • References
  • 58. Neonatal Seizures
  • Abstract
  • Neonatal Seizures
  • Classification of Neonatal Seizures
  • Evaluation of Neonatal Seizure
  • Etiologies of Neonatal Seizures
  • Neonatal Epilepsy Syndromes
  • Management of Neonatal Seizures
  • Outcomes of Neonatal Seizures
  • References
  • Suggested Readings
  • References
  • Part XIII: Gastrointestinal System and Nutrition
  • 59. Enteral Nutrition
  • Abstract
  • Macronutrient Requirements
  • Micronutrients, Vitamins, Minerals, and Trace Element Requirements
  • Options for Enteral Nutrition
  • Special Issues/Contraindications to Mother’s Own Milk
  • Donor Human Milk
  • Human Milk Fortification
  • Initiation, Mode, and Advancement of Enteral Feedings
  • Infant Nutrition and Growth
  • References
  • Suggested Readings
  • References
  • 60. Parenteral Nutrition for the High-Risk Neonate
  • Abstract
  • Components of Parenteral Nutrition
  • Complications of Parenteral Nutrition
  • Use of Parenteral Nutrition in the Neonatal Intensive Care Unit: A Practical Approach
  • References
  • Suggested Readings
  • References
  • 61. Structural Anomalies of the Gastrointestinal Tract
  • Disorders of the Oral Cavity
  • Disorders of the Neck
  • Disorders of the Esophagus
  • Disorders of the Stomach
  • Disorders of the Intestine
  • Disorders of the Colon and Anus
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 62. Abdominal Wall Defects
  • Abdominal Wall Problems
  • Abdominal Wall Defects
  • Gastroschisis
  • Omphalocele
  • Other Abdominal Wall Defects
  • Umbilical Abnormalities
  • Abdominal Wall Hernias
  • Umbilical Cord Abnormalities
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 63. Neonatal Gastroesophageal Reflux
  • Gastroesophageal Reflux
  • References
  • Suggested Readings
  • References
  • 64. Necrotizing Enterocolitis and Short Bowel Syndrome
  • Necrotizing Enterocolitis
  • Short Bowel Syndrome
  • References
  • Suggested Readings
  • References
  • 65. Disorders of the Liver
  • Neonatal Liver Disease
  • Cholestatic Liver Disease
  • Metabolic Liver Disease
  • Gestational Alloimmune Liver Disease
  • Vascular Malformations
  • Liver Masses
  • References
  • Suggested Readings
  • References
  • Part XIV: Hematologic System and Disorders of Bilirubin Metabolism
  • 66. Developmental Hematology
  • Introduction to Embryonic Hematopoiesis
  • Developmental Aspects of Erythropoiesis
  • Developmental Aspects of Megakaryocytopoiesis
  • Developmental Aspects of Granulocytopoiesis
  • Hematopoietic Cytokines
  • Acknowledgment
  • References
  • Suggested Readings
  • References
  • 67. Neonatal Bleeding and Thrombotic Disorders
  • The Neonatal Hemostatic System
  • Bleeding Disorders in the Neonate
  • Neonatal Thrombosis
  • References
  • References
  • Suggested Readings
  • 68. Neonatal Platelet Disorders
  • Fetal and Neonatal Platelet Production
  • Platelet Counts During Development and Reference Ranges
  • Platelet Function and Primary Hemostasis
  • Immune Thrombocytopenia
  • Neonatal Alloimmune Thrombocytopenia
  • Autoimmune Thrombocytopenia
  • Congenital Thrombocytopenias
  • Platelet Function Disorders
  • References
  • Suggested Readings
  • References
  • 69. Neonatal Erythrocyte Disorders
  • Normal Erythrocyte Physiology in the Fetus and Newborn
  • Anemia in the Fetus and Newborn
  • Hereditary Red Blood Cell Disorders
  • Hypoplastic Anemia
  • Physiologic Anemia of Infancy and Anemia Prematurity
  • Polycythemia
  • Methemoglobinemia
  • Acknowledgment
  • References
  • References
  • Suggested Readings
  • 70. Neonatal Transfusion
  • Overview
  • Red Blood Cell Transfusion
  • Platelet Transfusion
  • Plasma and Cryoprecipitate Transfusion
  • Special Circumstances
  • Decreasing the Need for Red Blood Cell Transfusion
  • References
  • Suggested Readings
  • References
  • 71. Neonatal Leukocyte Physiology and Disorders
  • Abstract
  • Neutrophil Physiology and Function
  • Monocyte Physiology and Dysfunction
  • Lymphocyte Contributing to Acquired Immunity
  • Dendritic Cell Physiology and Function
  • Innate Lymphoid Cell Physiology and Function
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • 72. Neonatal Hyperbilirubinemia and Kernicterus
  • Abstract
  • Hyperbilirubinemia
  • Increased Hepatic Bilirubin Load: Hemolytic Disease
  • Decreased Hepatic Bilirubin Clearance
  • Other Clinically Relevant Icterogenic Conditions
  • Kernicterus Spectrum Disorders
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • Part XV: Neoplasia
  • 73. Congenital Malignant Disorders
  • Abstract
  • Epidemiology, Etiology, and Diagnosis of Neonatal Malignancy
  • Specific Neoplasms
  • Treatment Considerations in Infants
  • Conclusion
  • References
  • Suggested Readings
  • References
  • Part XVI: Renal and Genitourinary System
  • 74. Renal Development
  • Abstract
  • Factors Influencing Organogenesis
  • Development of the Renal Vascular Bed
  • Renal Morphogenesis
  • Glomerular Development
  • Ureteral Growth and Development
  • Renin–Angiotensin System Interaction for Programming Fetal Development
  • Renal Ascent
  • Fetal Programing of Renal Function and the Perinatal Environmental Factor’s Influence
  • Conclusion
  • References
  • Suggested Readings
  • References
  • 75. Developmental Abnormalities of the Kidneys
  • Abstract
  • Abnormalities of Kidney Number
  • Abnormalities of Kidney Position
  • Abnormalities of Kidney Organization
  • Abnormalities With Kidney Overgrowth
  • Abnormalities Predominated by Kidney Cysts
  • Renal Tubular Dysgenesis
  • Kidney Teratogens
  • Inborn Errors of Metabolism
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • 76. Developmental Abnormalities of the Genitourinary System
  • Abstract
  • Early Kidney and Urinary Tract Embryologic Development
  • Anomalies of the Kidney
  • Anomalies of the Ureters
  • Anomalies of the Bladder
  • Genital Abnormalities in Males
  • Female Genital Anomalies
  • References
  • Suggested Readings
  • References
  • 77. Acute Kidney Injury
  • Abstract
  • Acute Kidney Injury
  • Acute Kidney Injury as a Cause of Long-Term Chronic Kidney Disease
  • Renal Vascular Disease in the Newborn
  • References
  • References
  • Suggested Readings
  • 78. Chronic Kidney Disease
  • Abstract
  • Chronic Kidney Disease
  • Epidemiology
  • Pathophysiology
  • Clinical Sequelae of Neonatal Chronic Kidney Disease/End-Stage Kidney Disease
  • Management
  • Outcomes
  • References
  • References
  • Suggested Readings
  • 79. Glomerulonephropathies and Disorders of Tubular Function
  • Abstract
  • Glomerulonephropathies
  • Renal Tubular Disorders
  • References
  • Suggested Readings
  • References
  • 80. Urinary Tract Infections and Vesicoureteral Reflux
  • Abstract
  • Urinary Tract Infection
  • Vesicoureteral Reflux
  • References
  • Suggested Readings
  • References
  • 81. Systemic Hypertension
  • Abstract
  • Factors that Influence Neonatal Blood Pressure
  • Epidemiology
  • Pathophysiology
  • Evaluation
  • Management
  • Outcomes
  • References
  • Suggested Readings
  • References
  • Part XVII: Endocrine Disorders
  • 82. Developmental Endocrinology
  • Abstract
  • Endocrine Systems
  • Endocrine Organ Development and Perinatal Transition
  • The Maternal-Placental-Fetal Unit
  • Hypothalamic and Pituitary Development
  • Diseases of Hypothalamic or Pituitary Maldevelopment
  • Adrenal Gland Development
  • Thyroid Gland Development
  • Reproductive Axis Development
  • Development of the Endocrine Pancreas
  • Development of Parathyroid Glands and Fetal Mineral Homeostasis
  • Hormonal Regulation of Fetal Growth
  • Developmental Origin of Health and Disease
  • References
  • Suggested Readings
  • References
  • 83. Disorders of Calcium and Phosphorus Metabolism
  • Non-Print Itemabstract
  • Homeostatic Control of Calcium and Magnesium
  • Homeostatic Control of Phosphorus
  • Parathyroid-Renal Hormonal Axis
  • Perinatal Mineral Metabolism
  • Metabolic Bone Disease in Newborns and Infants
  • Vitamin D–Deficiency Rickets
  • Renal Osteodystrophy
  • References
  • Suggested Readings
  • References
  • 84. Disorders of the Adrenal Gland
  • Non-Print ItemAbstract
  • The Adrenal Gland
  • Primary Adrenal Disorders
  • Disorders That Lead to Virilization in Females
  • Disorders That Lead to Males With Undervirilization
  • Adrenal Insufficiency Associated With Other Syndromic Disorders
  • Adrenal Hemorrhage
  • Secondary and Tertiary Adrenal Insufficiency
  • Adrenal Crisis in the Neonate
  • References
  • Suggested Readings
  • References
  • 85. Differences in Sex Development
  • Abstract
  • General Considerations in the Approach to the Newborn With Ambiguous Genitalia
  • Embryology of Sex Determination and Differentiation
  • Clinical Assessment of Differences of Sex Development
  • 46,XX Differences in Sex Development
  • 46,XY Differences in Sex Development
  • Gonadal Differentiation and Chromosomal Disorders
  • Syndromes Associated With Ambiguous Genitalia
  • Other Disorders of Genital Differentiation
  • Sex Chromosome Disorders of Sex Development
  • Surgical Management of Disorders of Sexual Differentiation
  • References
  • Suggested Readings
  • References
  • 86. Disorders of the Thyroid Gland
  • Non-Print ItemAbstract
  • Regulation of Thyroid Function
  • Thyroid Hormone Synthesis
  • Serum Protein Binding and Transport
  • Embryogenesis of Hypothalamic-Pituitary-Thyroid Axis
  • Fetal–Placental–Maternal Thyroid Interaction
  • Thyroid System Maturation
  • Congenital Hypothyroidism
  • Neonatal Hyperthyroidism
  • References
  • Suggested Readings
  • References
  • 87. Neonatal Hypoglycemia and Hyperglycemia
  • Abstract
  • Introduction
  • Neonatal Hypoglycemia
  • Normoinsulinemic Hypoglycemia
  • Hyperinsulinemic Hypoglycemia
  • Neonatal Hyperglycemia
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • Part XVIII: Craniofacial and Orthopedic Conditions
  • 88. Craniofacial Conditions
  • Abstract
  • Micrognathia/Robin Sequence
  • Stickler Syndrome
  • Orofacial Clefts
  • 22q11.2 Deletion Syndrome
  • Craniosynostosis
  • Multiple Suture Synostosis
  • Disorders of the First and Second Branchial Arches
  • Moebius Syndrome
  • Treacher Collins Syndrome
  • CHARGE Syndrome
  • Macroglossia/Beckwith-Wiedemann Syndrome
  • Other Notable Craniofacial Conditions
  • Prenatal Screening for Fetal Face Anomalies
  • Acknowledgment
  • References
  • Suggested Reading
  • References
  • 89. Common Neonatal Orthopedic Conditions
  • Abstract
  • Developmental Dysplasia of the Hip
  • Foot Deformities
  • Torticollis
  • Torsional and Angular Deformities of the Lower Extremities
  • Congenital Vertebral Malformations
  • Obstetric Trauma
  • Neonatal Osteomyelitis and Septic Arthritis
  • References
  • Suggested Readings
  • References
  • 90. Skeletal Dysplasias and Heritable Connective Tissue Disorders
  • Abstract
  • Clinical Spectra of Disorders With Common Molecular or Cellular Bases
  • Approach to Diagnosis
  • Clinical and Molecular Evaluation
  • Disorders of Bone Fragility
  • FGFR3 Spectrum
  • COL2A1 Spectrum
  • SLC26A2 Spectrum
  • Other Skeletal Dysplasias
  • Heritable Connective Tissue Disorders
  • Family Support and Education
  • References
  • Suggested Readings
  • References
  • Part XIX: Dermatologic Conditions
  • 91. Newborn Skin Development: Structure and Function
  • Epidermis
  • Dermoepidermal Junction
  • Dermis and Subcutis
  • Appendages
  • Specialized Skin Cells
  • Epidermal Stem Cells
  • Impact of Prematurity
  • Care of Preterm Skin
  • General Care of Newborn Skin
  • Morphologic Approach to Skin Pathology
  • Collodion Membrane
  • Vesicopustular and Bullous Eruptions
  • Blueberry Muffin Babies
  • Erythroderma
  • Birthmarks With Neurologic Implications
  • References
  • Suggested Readings
  • References
  • 92. Congenital and Hereditary Disorders of the Skin
  • Ichthyoses
  • Epidermolysis Bullosa
  • Ehlers–Danlos Syndrome
  • Cutis Laxa
  • Ectodermal Dysplasias
  • Incontinentia Pigmenti
  • Focal Dermal Hypoplasia (Goltz Syndrome)
  • Disorders With Generalized Hypopigmentation
  • Disorders With Localized Hypopigmentation
  • Congenital Erythropoietic Porphyria
  • Erythropoietic Protoporphyria and X-Linked Erythropoietic Protoporphyria
  • Hepatoerythropoietic Porphyria
  • References
  • Suggested Readings
  • References
  • 93. Infections of the Skin
  • Staphylococcus aureus Infections
  • Streptococcus Species Infections
  • Omphalitis
  • Candida Species Infections
  • Primary Cutaneous Aspergillosis
  • Tinea Capitis and Tinea Corporis
  • Herpes Simplex Virus Infection
  • Acknowledgments
  • References
  • Suggested Readings
  • References
  • 94. Common Newborn Dermatoses
  • Erythema Toxicum Neonatorum
  • Transient Neonatal Pustular Melanosis
  • Eosinophilic Pustular Folliculitis
  • Acropustulosis of Infancy
  • Milia
  • Miliaria
  • Diagnosis
  • Epstein Pearls and Bohn Nodules
  • Sebaceous Hyperplasia
  • Neonatal Cephalic Pustulosis (Neonatal Acne)
  • Seborrheic Dermatitis
  • Atopic Dermatitis
  • Diaper Dermatitis
  • Harlequin Color Change
  • Subcutaneous Fat Necrosis
  • Cutis Marmorata
  • Dermal Melanocytosis
  • Diagnosis
  • Aplasia Cutis Congenita
  • References
  • Suggested Readings
  • References
  • 95. Vascular Anomalies and Other Cutaneous Congenital Defects
  • Vascular Anomalies
  • Disorders of Pigmentation
  • Congenital Tumors of Epithelial Origin
  • Congenital Tumors of Dermal and Subcutaneous Origin
  • Developmental Anomalies of the Skin
  • References
  • Suggested Readings
  • References
  • Part XX: Eyes and Ears
  • 96. Eye and Vision Disorders
  • General Examination Techniques
  • Common Diagnostic Problems
  • Common Ophthalmic Manifestations of Systemic Diseases
  • Role of the Neonatal Healthcare Provider
  • Establishment of a Retinopathy of Prematurity Program
  • References
  • Suggested Readings
  • References
  • 97. Ear and Hearing Disorders
  • Normal Hearing
  • Permanent Hearing Loss—The Challenge
  • Hearing Disorders
  • Methods for Newborn Hearing Screening
  • Risk Factors for Permanent Hearing Loss in Infants and Children
  • Family
  • Neonatal
  • After Newborn Hearing Screening: Audiology Diagnostic Protocols
  • Medical Work-Up for Hearing Loss
  • Multidisciplinary Care
  • Communication Options
  • Comprehensive Early Intervention
  • Neonatal Intensive Care Unit Infants, Risk Factors, and Hearing Loss
  • The Brain, Language Outcomes, and Access to Language
  • References
  • Suggested Readings
  • References
  • Index
  • Confidence is ClinicalKey