Availability: Άμεσα Διαθέσιμο

Bayesian Precision Medicine

ISBN: 9781032754468
ISBN: 9781032754468
Εκδόσεις:
Διαστάσεις 24 × 16 cm
Μορφή

Hardback

Εκδόσεις

Ημ. Έκδοσης

2024/05

Σελίδες

340

Έκδοση

1η έκδοση

Κύριος Συγγραφέας

107,00€(Περιλαμβάνεται ΦΠΑ 6%)

Διαθεσιμότητα: 23-28 ημέρες

Περιγραφή

Bayesian Precision Medicine presents modern Bayesian statistical models and methods for identifying treatments tailored to individual patients using their prognostic variables and predictive biomarkers.  The process of evaluating and comparing treatments is explained and illustrated by practical examples, followed by a discussion of causal analysis and its relationship to statistical inference.  A wide array of modern Bayesian clinical trial designs are presented, including applications to many oncology trials. The later chapters describe Bayesian nonparametric regression analyses of datasets arising from multi-stage chemotherapy for acute leukemia, allogeneic stem cell transplantation, and targeted agents for treating advanced breast cancer.

Features:

  • Describes the connection between causal analysis and statistical inference
  • Reviews modern personalized Bayesian clinical trial designs for dose-finding, treatment screening, basket trials, enrichment, incorporating historical data, and confirmatory treatment comparison, illustrated by real-world applications
  • Presents adaptive methods for clustering similar patient subgroups to improve efficiency
  • Describes Bayesian nonparametric regression analyses of real-world datasets from oncology
  • Provides pointers to software for implementation

Bayesian Precision Medicine is primarily aimed at biostatistician and medical researcher who desire to apply modern Bayesian methods to their own clinical trials and data analyses. It also might be used to teach a special topics course on precision medicine using a Bayesian approach to postgraduate biostatistics students. The main goal of the book is to show how Bayesian thinking can provide a practical scientific basis for tailoring treatments to individual patients.

Περιεχόμενα

1. Evaluating New Treatments
2. Statistics and Causality
3. Precision Dose Optimization
4. Bayesian Basket Trials
5. Precision Randomized Phase II Designs
6. Precision Phase III Designs
7.Enrichment Concepts and Methods
8. Adaptive Enrichment Designs
9. Bayesian Nonparametric Models
10. Evaluating Multistage Treatment Regimes for Acute Leukemia
11. Personalizing Preparative Regimen in Stem Cell Transplantation
12. Utilities for Personalizing Advanced Breast Cancer Treatment