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Diagnostic Pathology: Neuropathology, 3rd Edition

ISBN: 9780323713306
Διαστάσεις 28 × 22 cm



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Covering all aspects of neuropathology, this updated volume in the Diagnostic Pathology series is an excellent point-of-care resource for pathologists at all levels of experience and training—both as a quick reference and as an efficient review to improve knowledge and skills. The third edition is an easy-to-use, one-stop reference for the most recent clinical, pathological, histological, and molecular knowledge in the field. It offers complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions, enabling you to arrive at the correct diagnosis and prepare actionable, useful reports.

Key Features
    • Incorporates new WHO Classification of Tumors of the Central Nervous System, 5th Edition


    • Offers information on neoplasms of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, and vascular lesions, aiding you in arriving at the correct diagnosis



    • Emphasizes surgical pathology but also provides significant content on nonneoplastic diseases that present with focal lesions, especially those that are potentially misinterpreted as neoplasms



    • Features new and updated chapters detailing several types of tumors that have been reclassified due to recent molecular driver information, cIMPACT-NOW recommendations, and the WHO Classification, 5th Edition



    • Features nearly 1,700 annotated images throughout, including neuroimaging studies, histology and immunohistochemical stains, and high-quality medical illustrations



  • Incorporates time-saving features such as a templated, highly formatted design; concise, bulleted text; a variety of test data tables; key facts in each chapter; and an extensive index
  • Includes the enhanced eBook version, which allows you to access all text, figures, and references on a variety of devices
Author Information
By B.K. Kleinschmidt-DeMasters, MD, Professor of Pathology, Neurology, and Neurosurgery, Director of Neuropathology, University of Colorado School of Medicine, Aurora, Colorado; Melike Pekmezci, MD, Associate Professor of Pathology and Ophthalmology, Department of Pathology and Ophthalmology, University of California, San Francisco; Staff Pathologist, San Francisco Veterans Affairs Medical Center, San Francisco, California; Fausto Rodriguez, MD, Assistant Professor of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland; and Tarik Tihan, MD, PhD, Professor of Pathology, Neuropathology Division, University of California San Francisco School of Medicine, San Francisco, California




Brain and Spinal Cord

Diffuse Astrocytic and Oligodendroglial Tumors

Diffuse Astrocytoma, IDH-Mutant, WHO Grade II

Diffuse Astrocytoma, IDH-Wildtype, WHO Grade II (Provisional Entity)

Anaplastic Astrocytoma, IDH-Mutant, WHO Grade III

Anaplastic Astrocytoma, IDH-Wildtype, WHO Grade III

Glioblastoma, IDH-Wildtype

Granular Cell Astrocytoma of the Cerebrum


Glioblastoma, IDH Mutant

Diffuse Midline Glioma, H3 K27M Mutant

H3 G34-Mutant Gliomas, IDH-Wildtype (Provisional Entity)


Anaplastic Oligodendroglioma

Mixed Oligoastrocytoma

Other Astrocytic Tumors

Pilocytic Astrocytoma

Pilomyxoid Astrocytoma

Subependymal Giant Cell Astrocytoma

Pleomorphic Xanthoastrocytoma

Anaplastic Pleomorphic Xanthoastrocytoma

Pediatric Low-Grade Glioma/Glioneuronal Tumors (Provisional Entities)

Ependymal Tumors


Myxopapillary Ependymoma


Ependymoma, *RELA* Fusion-Positive

Anaplastic Ependymoma

Other Gliomas

Chordoid Glioma of 3rd Ventricle

Angiocentric Glioma


Choroid Plexus Tumors

Choroid Plexus Papilloma and Atypical Papilloma

Choroid Plexus Carcinoma

Neuronal and Mixed Neuronal-Glial Tumors

Dysembryoplastic Neuroepithelial Tumor

Gangliocytoma and Ganglioglioma

Dysplastic Cerebellar Gangliocytoma (Lhermitte-Duclos Disease)

Desmoplastic Infantile Ganglioglioma

Papillary Glioneuronal Tumor

Rosette-Forming Glioneuronal Tumor of 4th Ventricle

Diffuse Leptomeningeal Glioneuronal Tumor

Malignant Glioneuronal Tumors

Central Neurocytoma

Extraventricular Neurocytoma

Cerebellar Liponeurocytoma

Paraganglioma of Filum Terminale

Tumors of the Pineal Region

Pineal Parenchymal Neoplasms

Papillary Tumor of the Pineal Region

Pineal Anlage Tumor

Embryonal Tumors


CNS Embryonal Neoplasms

Embryonal Tumor With Multilayered Rosettes, C19MC Altered

Ewing Sarcoma

Atypical Teratoid/Rhabdoid Tumor

Germ Cell Tumors



Other Germ Cell Tumors

Lymphomas and Histiocytic Tumors

Primary Central Nervous System Lymphoma

Lymphomatosis Cerebri

Lymphomatoid Granulomatosis

Intravascular Lymphomatosis

Primary Amyloidoma

Langerhans Cell Histiocytosis

Erdheim-Chester Disease

Rosai-Dorfman Disease

Metastatic Tumors

Metastatic Neoplasms, Intraparenchymal, Brain and Spinal Cord

Sellar Region

Adenohypophyseal Neoplasia and Hyperplasia

Pituitary Adenoma


Somatotroph Adenoma

Corticotroph Adenoma

Gonadotroph Adenoma

Thyrotroph Adenoma

Plurihormonal Adenoma

Null Cell Adenoma

Pituitary Hyperplasia

Pituitary Carcinoma

TTF-Mediated Neurohypophyseal Neoplasms

Granular Cell Tumor of the Sellar Region


Spindle Cell Oncocytoma


Adamantinomatous Craniopharyngioma

Papillary Craniopharyngioma

Miscellaneous Neoplasms

Pituitary Blastoma

Secondary Neoplasms of the Pituitary and Sellar Region

Hypothalamic Hamartoma

Meningiomas and Mesenchymal Nonmeningothelial Tumors


Solitary Fibrous Tumor/Hemangiopericytoma


Primary Melanocytic Neoplasms

Osteocartilaginous Neoplasms

Notochordal Tumors


Smooth Muscle Neoplasms

Adipocytic Neoplasms

Meningeal Glioma and Gliomatosis

Metastatic Neoplasms, Intracranial and Intraspinal Meninges

Tumors of Cranial and Paraspinal Nerves

Schwannoma Variants

Conventional Schwannoma

Cellular Schwannoma

Plexiform Schwannoma

Melanotic Schwannoma


Plexiform Neurofibroma

Localized Intraneural Neurofibroma

Extraneural Neurofibroma Variants


Intraneural Perineurioma

Soft Tissue Perineurioma

Primary Malignant Neoplasms of Nerve

Malignant Peripheral Nerve Sheath Tumor

Lipoma of 8th Cranial Nerve

Lipoma of 8th Cranial Nerve

Familial Tumor Syndromes


Neurofibromatosis 1

Neurofibromatosis 2



von Hippel-Lindau Syndrome

Tuberous Sclerosis Complex

Turcot Syndrome


Benign Cysts

Arachnoid Cyst

Epidermoid and Dermoid Cysts

Colloid Cyst

Rathke Cleft Cyst

Endodermal Cyst

Ependymal Cyst

Pineal Cyst

Facet Joint Synovial Cyst

Infectious, Inflammatory, and Reactive Lesions

Demyelinating Diseases

Demyelinating Disease (Multiple Sclerosis-Tumefactive Demyelination)

Bacterial Infections

Abscess and Cerebritis

Whipple Disease


Viral Infections

Herpes Simplex Encephalitis

Progressive Multifocal Leukoencephalopathy

HIV Encephalitis

Other Viral Infections

Fungal Infections

Fungal Infections

Protozoal and Parasitic Infections




Miscellaneous Parasitic Infections

Other Inflammatory Diseases


Rasmussen Encephalitis

Paraneoplastic Disease

Textiloma (Muslinoma, Gauzoma, Gossypiboma)

Inflammatory Pseudotumors

Lymphocytic Hypophysitis

Reactive Conditions and Noninflammatory Pseudoneoplasms


Meningeal Response to Intracranial Hypotension

Radiation Necrosis

Calcifying Pseudoneoplasm of the Neuraxis

Vascular Diseases

Vascular Malformations and Neoplasms


Cavernous Angioma

Arteriovenous Malformation

Capillary Hemangioma

Vascular Lesions

Subdural Hematoma


Vasculitis and Vasculopathy

Primary Angiitis of Central Nervous System

Amyloid (Congophilic) Angiopathy

Cortical Dysplasia

Cortical Dysplasia