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Endometriosis: Science and Practice

ISBN: 9781444332131
ISBN: 9781444332131

Ημ. Έκδοσης







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Written by an internationally well-known editor team, Endometriosis: Science and Practice is a state-of-the-art guide to this surprisingly common disease. While no cause for endometriosis has been determined, information of recent developments are outlined in this text, offering insight to improve management of symptoms medically or surgically. The first of its kind, this major textbook integrates scientific and clinical understanding of this painful disease helping to provide better patient care.


List of Contributors, viii

Preface, xiii

List of Abbreviations, xv

Part 1: History, Epidemiology, and Economics

1 History of Endometriosis: A 20th-Century Disease, 3
Ivo Brosens and Giuseppe Benagiano

2 Endometriosis: Epidemiology, and Etiological Factors, 19
Fabio Parazzini, Paolo Vercellini and Claudio Pelucchi

3 Economic Perspective on Diagnosis and Treatment of Endometriosis, 27
Steven Simoens and Thomas M. D?Hooghe

Part 2: Pathogenesis

4 Pathogenesis: Development of the Female Genital Tract, 35
Jolande A. Land and Johannes L.H. Evers

5 Theories on the Pathogenesis of Endometriosis, 42
Annemiek W. Nap

6 Understanding the Pathogenesis of Endometriosis: Gene Mapping Studies, 54
Jodie N. Painter, Krina T. Zondervan and Grant W. Montgomery

7 Pathogenesis: Epigenetics, 65
Sun-Wei Guo

Part 3: Disease Characterization

8 Endometriosis: Disease Classification and Behavior, 81
G. David Adamson

9 Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities, 92
Jacques Donnez, Olivier Donnez, Jean-Christophe Lousse and Jean Squifflet

10 Extra-abdominal Endometriosis, 108
Antonio Bobbio, Diane Damotte, Anne Gompel and Marco Alifano

Part 4: Biological Basis and Pathophysiology of Endometriosis

11 Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis, 117
Petra A. B. Klemmt and Anna Starzinski-Powitz

12 Stem Cells in Endometriosis, 130
Caroline E. Gargett, Hirotaka Masuda and Gareth C. Weston

13 Role of Steroid Hormones: Estrogen and Endometriosis, 140
Elke Winterhager

14 Role of Steroid Hormones: Progesterone Signaling, 145
Shirin Khanjani, Marwa K. Al-Sabbagh, Luca Fusi and Jan J. Brosens

15 Early Origins of Endometriosis: Role of Endocrine Disrupting Chemicals, 153
Germaine M. Buck Louis

16 Signaling Pathways in Endometriosis (Eutopic/Ectopic), 164
J. Julie Kim and Xunqin Yin

17 MicroRNAs in Endometriosis, 173
M. Louise Hull and Cristin G. Print

18 HOX Genes and Endometriosis, 184
Jennifer L. Kulp, Hakan Cakmak and Hugh S. Taylor

19 Angiogenesis and Endometriosis, 190
Patrick. G. Groothuis

20 Uterine Peristalsis and the Development of Endometriosis and Adenomyosis, 200
Gerhard Leyendecker and Ludwig Wildt

21 Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis, 212
Ian S. Fraser, Natsuko Tokushige, Alison J. Hey-Cunningham, Marina Berbic and Cecilia H. M. Ng

22 Neuroendocrine Aspects of Endometriosis-Associated Pain, 230
Pamela Stratton and Karen J. Berkley

23 Pathophysiology of Infertility in Endometriosis, 240
Bruce A. Lessey and Steven L. Young

24 Inflammation and Endometriosis, 255
Daniela Hornung and Ursula von Wussow

Part 5: Models of Endometriosis

25 Models of Endometriosis: In vitro and In vivo Models, 265
Ruth Gr?mmer

26 Models of Endometriosis: Animal Models I ? Rodent-based Chimeric Models, 270
Kaylon L. Bruner-Tran, Melinda E. McConaha and Kevin G. Osteen

27 Models of Endometriosis: Animal Models II ? Non-human Primates, 285
Asgerally T. Fazleabas

Part 6: Diagnosis of Endometriosis

28 Surgical Historical Overview, 295
Ayman Al-Talib and Togas Tulandi

29 Diagnosis of Endometriosis: Imaging, 299
Gerard A. J. Dunselman and Regina G. H. Beets-Tan

30 Diagnosis of Endometriosis: Biomarkers, 309
Beata E. Seeber and Kurt T. Barnhart

31 Diagnosis of Endometriosis: Proteomics, 324
Andrew N. Stephens, Luk J. F. Rombauts and Lois A. Salamonsen

32 Diagnosis of Endometriosis: Transcriptomics, 336
Richard O. Burney and Linda C. Giudice

Part 7: Medical Therapies for Pain

33 Medical Therapies: Randomized Controlled Trials/Traditional Medical Therapies, 343
Neil P. Johnson

34 Medical Therapies: Progestins, 351
Andrew Horne and Hilary O. D. Critchley

35 Medical Therapies: Aromatase Inhibitors, 357
Serdar E. Bulun, Erkut Attar, Bilgin Gurates, You-Hong Chen, Hideki Tokunaga, Diana Monsivais and Mary Ellen Pavone

36 Medical Therapies: Statins, 366
Anna Sokalska and Antoni J. Duleba

Part 8: Surgical Therapies for Pain

37 Surgical Therapies: Principles and Triage in Endometriosis, 387
Alan Lam, Tommaso Bignardi and Su-Yen Khong

38 Surgical Therapies: Peritoneal Endometriosis Surgery, 396
Michael P. Diamond and Valerie I. Shavell

39 Surgical Therapies: Pouch of Douglas and Uterovaginal Pouch Resection for Endometriosis, 402
Maur?cio S. Abr?o, S?rgio Podgaec and Luiz Fl?vio Cordeiro Fernandes

40 Surgical Therapies: Randomized Controlled Trials in Endometriosis, 410
Jason Abbott

41 Surgical Therapies: Rectal/Bowel Endometriosis, 419
Jim Tsaltas

42 Surgical Therapies: Ureteric Dissection and Urological Endometriosis, 426
Anna Rosamilia and Caroline Dowling

43 Surgical Therapies: Robotics and Endometriosis, 438
Camran Nezhat, Arathi Veeraswamy and Chandhana Paka

Part 9: Infertility and Endometriosis

44 Medical Therapy of Endometriosis: Subfertility, 449
Johannes L. H. Evers

45 Infertility Therapies: The Role of Surgery, 455
Oswald Petrucco and David L. Healy

46 Infertility Therapies: The Role of Assisted Reproductive Technologies, 462
Kimberly Moon, Jeris Cox and Alan DeCherney

47 Ovarian Endometrioma: Surgery and Fertility Preservation, 473
Luk J. F. Rombauts

Part 10: Associated Disorders

48 Endometriosis and Autoimmunity, 485
Srinu Pathivada and Thomas D?Hooghe

49 Endometriosis and Cancer: Epidemiology, 501
Paola Vigan?, Edgardo Somigliana, Fabio Parazzini and Paolo Vercellini

50 Molecular Mechanisms Underlying Endometriosis and Endometriosis-Related Cancers, 512
Daniela Dinulescu

51 Pregnancy and Obstetric Outcomes in Women with Endometriosis, 519
Henrik Falconer

52 Sexuality in Endometriosis, 524
Brigitte Leeners

53 Psychosomatic Aspects, 533
Brigitte Leeners

54 Endometriosis in the Adolescent Patient, 548
Claire Templeman

55 Fertility Preservation in Patients with Endometrioma, 555
Jennifer Hirshfeld-Cytron, Candace Tingen and Teresa K. Woodruff

56 Eye to the Future: Research, Diagnostics, and Therapeutics, 560
Peter A.W. Rogers and Gareth C. Weston

Index, 565

The color plate section can be found facing p.78