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Hematology, 2nd Edition. A Pathophysiologic Approach (Mosby Physiology Series)

ISBN: 9780323595834
ISBN: 9780323595834
Διαστάσεις 24 × 19 cm



Ημ. Έκδοσης





2η έκδοση

Κύριος Συγγραφέας

41,00(Περιλαμβάνεται ΦΠΑ 6%)

Διαθεσιμότητα: 11-14 ημέρες


Gain a foundational understanding of complex hematology concepts with this thoroughly revised text. Hematology: A Pathophysiologic Approach, 2nd Edition, a volume in the?Mosby Physiology Series,?explains the fundamentals of this multi-faceted area in a clear and concise manner. It offers masterful explanations of hematopoiesis, immunology, hemostasis, hemoglobinopathy, metabolic disorders, genetics, and neoplasia from S. David Hudnall, MD, Professor Emeritus of Pathology and Laboratory Medicine at Yale University School of Medicine. Prof. Hudnall, who has practiced laboratory hematology and hematopathology for more than 30 years, has taught the principles of hematology to thousands of pre-medical undergraduates and medical students. Rich, clinically oriented coverage from cover to cover makes this text an ideal, problem-based way to learn about this complex subject.
Key Features
  • Offers an accessible yet thorough understanding of hematolymphoid physiology and pathophysiology, helping you easily master the material in a systems-based curriculum?with learning objectives, Clinical Concept boxes, highlighted key words and concepts, chapter summaries, and end-of-chapter review questions.
  • Clearly explains interrelationships between the diverse factors that can give rise to disease.
  • Covers a wide range of subjects, including platelets and coagulation,  transfusion medicine, cytotoxic chemotherapy, infections, the immune system, and bone marrow transplantation.
  • Shows how hematologic disorders are evaluated through blood counting, histopathology, immunohistochemistry, cytogenetics, and coagulation testing.
  • Features 150 full-color photomicrographs to help you visualize a wide spectrum of hematologic pathology.
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Author Information
By S. David Hudnall, MD, FCAP, Professor of Pathology and Laboratory Medicine, Division Chief of Hematopathology, University of Texas Medical Branch, Galveston, TX


Cover image
Title page
Table of Contents
Preface to the second edition
List of Illustrations
List of Tables
1. Brief overview of the hematolymphoid system
Key words and concepts
2. Hematopoiesis
Technical considerations
Key words and concepts
3. Erythropoiesis and oxygen transport
Oxygen transport
Key words and concepts
4. Iron, heme, and hemoglobin
Iron uptake in the duodenum
Iron storage and regulation: Hepatocytes
Iron storage and recycling: Macrophages
Iron-deficiency anemia
Sideroblastic anemia
Hemoglobin oxygen affinity
Key words and concepts
5. Hemoglobinopathy
Nonfunctional hemoglobin variants
Beta-globin mutations
Unstable hemoglobin variants
Key words and concepts
6. Red blood cell metabolism and enzyme defects
Red blood cell enzyme defects
Key words and concepts
7. Hemolytic anemia
Extrinsic hemolytic anemia
Intrinsic hemolytic anemia
Key words and concepts
8. Aplastic anemia and related disorders
Anemia secondary to nonhematopoietic disease
Key words and concepts
9. Megaloblastic anemia
Key words and concepts
10. Myeloid cells
Basophils and mast cells
Key words and concepts
11. Immune system and related disorders
T cells
B cells
Immunoglobulin structure and function
T-cell receptor signaling
T-cell subsets
Lymphoid tumors
Key words and concepts
12. Genetic basis of hematologic neoplasia
Cell proliferation
Specific genetic defects in hematologic cancer
Molecular and cytogenetic techniques
Key words and concepts
13. Leukemia and related disorders
Acute myeloid leukemia
Acute lymphoblastic leukemia (precursor lymphoblastic leukemia)
Chronic lymphocytic leukemia
Myelodysplastic syndromes
Myeloproliferative neoplasms
Myelodysplastic/myeloproliferative diseases
Key words and concepts
14. Lymphoma and related disorders
B-cell non-hodgkin lymphoma
T-cell and natural killer cell lymphoma
Hodgkin lymphoma
Classic hodgkin lymphoma
Histiocytic and dendritic cell neoplasms
Key words and concepts
15. Blood coagulation
Blood coagulation
Bleeding disorders
Hereditary thrombophilia
Coagulation testing
Key words and concepts
16. Platelets
Thrombocytopenia and thrombocytosis
Platelet function defects
Key words and concepts
17. Benign conditions of lymphoid organs
Key words and concepts
18. Blood transfusion and stem cell transplantation
Blood transfusion
Blood groups
Transfusion reactions
Stem cell transplantation
Complications of allogeneic stem cell transplantation
Human leukocyte antigens
Key words and concepts
19. Hematologic cancer therapy
Cell-cycle active agents
Non–cell-cycle active agents
Key words and concepts
Appendix A. Answers to review questions
Appendix B. Complete blood count
Appendix C. Some useful immunophenotypic markers for hematologic diagnosis