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Image-guided Focused Ultrasound Therapy. Physics and Clinical Applications

ISBN: 9781498711357
ISBN: 9781498711357
Διαστάσεις 25 × 18 cm



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Ultrasound has been widely used in diagnostic imaging for a long time. In the past ten years, image-guided focused ultrasound therapy has seen rapid growth, in biomedical science and engineering, and in clinical medicine. The purpose of this book is to bring internationally renowned authorities and experts in this field together to provide up-to-date and comprehensive reviews of basic physics, biomedical engineering and clinical applications of focused ultrasound therapy in a widely accessible fashion.

Focusing on applications in cancer treatment, this book covers basic principles, practical aspects, and clinical applications of focused ultrasound therapy. It reviews the medical physics and bio-effects of focused ultrasound beams on living tissues, dosimetric methods and measurements, transducer engineering, image guidance and monitoring including MRI and ultrasound, treatment delivery systems and clinical applications. The book also gives practical guidelines on patient setup, target localisation, treatment planning and image-guided procedures for the treatment in various sites, including the prostate, liver, pancreas, breast, kidney, uterus, bone and brain.

The book discusses major challenges for the use of focused ultrasound energy on living tissues and explores the cellular and physiological responses that can be employed in the fight against cancer from biological, physics and engineering perspectives. It also highlights recent advances, including the treatment of solid tumours using image-guided drug delivery, and the exploitation of microbubbles, nanoparticles, and other cutting-edge techniques. Readers who are interested in learning more about the technique and clinical applications described in each chapter can find more information in the comprehensive bibliographies provided.

This book is suitable for anyone involved in, or looking to become involved in, the research and clinical applications of focused ultrasound therapy, including medical professionals, physicists, biomedical engineers, graduate students and others working in this multidisciplinary field. It offers a balanced and critical assessment of state-of-the-art technologies, major challenges, and an outlook on the future of focused ultrasound therapy. It presents a thorough introduction for those new to the field while providing helpful, up-to-date information and guidelines for readers already using this therapy in clinical and pre-clinical settings.

Key Features:

·         Brings together a wide range of world-leading experts in this new field, presenting the latest clinical outcomes of using focused ultrasound for the treatment of benign and malignant diseases.

·         Covers the fundamental physics of focused ultrasound therapy and ultrasound-mediated drug delivery, including chapters on the mechanism of sonoporation, microbubble and ultrasound interaction, and their potential clinical applications.

·         Introduces clinical guidelines for focused ultrasound therapy, including indications and contraindications, treatment goals, the selection of patients, clinical observation during treatment procedure and follow-up, and characteristics of image changes aftertreatment.



Chapter 1: Image-Guided Focused Ultrasound Therapy: Past, Current and Future. Chapter 2: Physical Principles of Focused Ultrasound Therapy. Chapter 3: Mechanisms for Induction of Bio-Effects of Focused Ultrasound in Tissue. Chapter 4: Image-Guided Focused Ultrasound Therapy: Physics and Clinical Applications. Chapter 5: Calibration and quality assurance for high intensity focused ultrasound fields. Chapter 6: Numerical Modelling for Simulation and Planning of Focused Ultrasound Treatments. Chapter 7: Ultrasound Monitoring Techniques for Focused Ultrasound Therapy. Chapter 8: Extracorporeal Ultrasound-guided HIFU Device and Clinical Application, Treatment Planning and B-mode Ultrasound for Real-time Monitoring and Controlling of Treatment. Chapter 9: Imaging Assessments of Tumour Response and Treatment Outcome after High-intensity Focused Ultrasound Ablation. Chapter 10: Focused Ultrasound Treatment of the Prostate: Devices and Clinical Results. Chapter 11: US-Guided Focused Ultrasound Ablation for Uterine Fibroids. Chapter 12: Clinical Application of Ultrasound-Guided Focused Ultrasound Ablation for Liver Tumours. Chapter 13: Clinical Application of Ultrasound-Guided Focused Ultrasound Ablation for Kidney Tumours. Chapter 14: Clinical Application of Ultrasound-Guided Focused Ultrasound Ablation for Pancreatic Cancer. Chapter 15: Clinical Application of Ultrasound-Guided Focused Ultrasound Ablation for Breast Tumours. Chapter 16: Clinical Application of Ultrasound-guided High Intensity Focused Ultrasound Treatment for Primary Bone Malignancies and Soft Tissue Sarcomas. Chapter 17: Clinical Extracorporeal MR-Guided Focused Ultrasound (MRgFUS) Systems: Treatment Planning, Therapy Delivery, and Online Monitoring via Thermometry and Thermal Dose Mapping. Chapter 18: Clinical Application of MR-Guided Focused Ultrasound Ablation for Uterine Fibroids. Chapter 19: Clinical Application of MR-Guided Focused Ultrasound Ablation for Tumours in the Breast. Chapter 20: Clinical Application of MR-Guided Focused Ultrasound Ablation for Bone Metastasis. Chapter 21: Clinical Application of MR-Guided Focused Ultrasound Therapy in the Brain. Chapter 22: Sonoporation: Concept, Mechanisms and Application to Cancer Treatment. Chapter 23: Nano/Microbubble-assisted Ultrasound for Drug Delivery in Cancer. Chapter 24: Anaesthesia, Ventilation and immobilisation Strategies for Focused Ultrasound Therapy (with special reference to high frequency ventilation). Chapter 25: Triggered Temperature-Sensitive Liposome Rlease by Focused Ultrasound for Localised Drug Delivery. Chapter 26: Transcranial Ultrasound-Mediated Blood-Brain Barrier Disruption for Targeted Drug Delivery. Chapter 27: Histotripsy: Focused Ultrasound Therapy by Mechanical Tissue Fractionation. Chapter 28: Focused Ultrasound Ablation Enhancement of Specific Antitumour Immunity. Chapter 29: Focused Ultrasound Therapy for Treatment of Pain.