The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease, and cystic fibrosis, etc., resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.
- Highlights the role the lungs play as an interface between the body and the environment.
- Describes the underlying mechanism of lung diseases.
- Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function.
- Includes contributions from leading researchers.