Availability: Άμεσα Διαθέσιμο

Lung Biology and Pathophysiology 1st Edition

ISBN: 9781032409023
ISBN: 9781032409023
Διαστάσεις 25 × 18 cm



Ημ. Έκδοσης





1η έκδοση

Κύριος Συγγραφέας

140,00€(Περιλαμβάνεται ΦΠΑ 6%)

Διαθεσιμότητα: Υπό έκδοση


The lungs are the organ for gas exchange between the body and the external environment. Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma, chronic obstructive pulmonary disease, and cystic fibrosis, etc., resulting in airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas exchange. In addition to lung structural cells, immune cells including alveolar macrophages and lymphocytes play critical roles in the maintenance of lung function. This book contributes to the understanding homeostasis of lung cells in the physiological and pathological conditions critical to the development of novel therapeutics.

Key Features

  • Highlights the role the lungs play as an interface between the body and the environment.
  • Describes the underlying mechanism of lung diseases.
  • Emphasizes the ways nutrition contributes to lung health as well as the ways pollution adversely affect lung function.
  • Includes contributions from leading researchers.


Editor Biography

List of Contributors


                Yutong Zhao


Part I: Lung Health and Pulmonary Diseases

Chapter 1             Antimicrobial Peptides in Lung Health and Pulmonary Diseases

                                Jenna M. Kuhn and Yuanpu Peter Di

Chapter 2             Alveolar Epithelium in Lung Injury and Repair

                                SeungHye Han

Chapter 3             Environmental Toxicants in Lung Diseases

                Samuel J. Cochran, Evangeline Schott, Brett Saunders, and Kymberly M. Gowdy

Chapter 4             Epigenetic Modifications of Histone in Lung Fibrosis

                                Yan Y. Sanders

Chapter 5             Translational Potential of Hypoxia-inducible factor-2α Signaling in Pulmonary Hypertension

                Zhiyu Dai

Part II: Research Strategies and Methods in Lung Biology and Pathophysiology

Chapter 6             Utility of Lung Organoids to Accelerate Our Understanding of Human Pulmonary Development and Diseases

                                Nicole Pek and Mingxia Gu

Chapter 7             Establishment of Animal Models of Pulmonary Fibrosis

                                Maolin Yao, Mo Chen, and Lian Li

Chapter 8             Research Strategies for Investigating Protein Ubiquitination in Lung Diseases

                                Yutong Zhao

Chapter 9             Peroxidative Metabolism of Lung Lipids in Pulmonary Health and Disease: Emphasis on Methods of Analysis of Oxidative Modification of Polyunsaturated Membrane Phospholipids

Austin C. Elliott, Lasya Kopuri, Surya Narla, Patrick J. Oliver, Anita Yenigalla, Elliott D. Crouser, Krishna Rao Maddipati, Thomas J. Hund, Narasimham L. Parinandi

Part III: Pathogenesis and Therapies of COVID-19

Chapter 10          Renin-Angiotensin System (RAS) and COVID-19: Exploring the Impact, Inhibition, and Treatment Strategies

                Qing Lin and Hongpeng Jia

Chapter 11          COVID-19 Therapeutics: Challenges and Opportunities

                                Travis B. Lear, Bill B. Chen, and Yuan Liu

Chapter 12          Clinical manifestations and pathogenesis of COVID-19 pulmonary disease

                                Moemen Eltobgy, Finny Johns, and Joseph S. Bednash

Part IV: Traditional Chinese Medicine in Lung Diseases

Chapter 13          Pulmonary Diseases and Traditional Chinese Medicine

                                Baochang Zhao, Xiaohong Shu, and Hong Zhang