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MacSween’s Pathology of the Liver, 8th Edition

ISBN: 9780702082283
Διαστάσεις 28 × 22 cm



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8η έκδοση



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268,00€(Περιλαμβάνεται ΦΠΑ 6%)

Διαθεσιμότητα: 11-14 ημέρες


Written and edited by an international team of renowned authorities, MacSween’s Pathology of the Liver, 8th Edition, remains the field’s definitive reference on liver pathology. This must-have text is ideal for surgical pathologists in practice and in training who examine liver specimens on a day-to-day basis. It provides invaluable assistance in recognizing the huge variety of appearances of the liver that result from infections, tumors, and tumor-like lesions, as well as organ damage caused by drugs and toxins. With expert, comprehensive coverage of all malignant and benign hepatobiliary disorders, MacSween’s is a convenient, one-stop resource for use in the reporting room as well as in personal study.
Key Features
  • Shares the knowledge and experience of a “who’s who” list of experts in the field of hepatobiliary pathology, led by editors Alastair D. Burt, Linda D. Ferrell, and Stefan G. Hübscher.
  • Features more than 1,000 high-quality, full color illustrations, providing a complete visual guide to each tumor or tumor-like lesion.
  • Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted/personalized medicine.
  • Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants, and new histologic entities.
  • Includes relevant data from ancillary techniques (immunohistochemistry, cytogenetics, and molecular genetics), giving you the necessary tools required to master the latest breakthroughs in diagnostic technology.
  • Provides you with all of the necessary diagnostic tools to make a complete and accurate pathologic report, including clinicopathologic background throughout.
  • Directs you to the most recent and authoritative sources for further reading with a comprehensive reference list that highlights key articles and up-to-date citations.
  • An eBook version is included with purchase. The eBook allows you to access all of the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud.
Author Information
By Alastair D. Burt, BSc, MBChB, MD, FRCPath, FRCPA, FRCP, FRSB, FAHMS, Professor of Precision and Molecular Pathology, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK; Emeritus Professor Faculty of Health and Medical Sciences, University of Adelaide, Australia ; Linda D. Ferrell, MD, Emerita Professor, Anatomic Pathology, University of California San Francisco, San Francisco, CA, USA and Stefan G. Hübscher, MBChB, FRCPath , Emeritus Professor of Hepatic Pathology, University of Birmingham, Birmingham, UK


Cover Image
Title Page
Table of Contents
Chapter 1 Structure, Function and Responses to Injury
Development of the liver
Macroanatomy of the liver
Microanatomy of the liver
Vascular injury and remodelling
Evolution of chronic liver diseases
The liver in biopsy, surgical and autopsy specimens
Chapter 2 Cellular and Molecular Techniques
Liver biopsy
Routine handling, fixation and staining of liver specimens
Molecular techniques
Other microscopic and optical techniques
Digital pathology for deep learning approaches and daily practice
Chapter 3 Developmental and Inherited Liver Disease
Diagnostic approach to histology
Neonatal hepatitis
Biliary atresia
Paucity of intrahepatic bile ducts
Bile duct anomalies, congenital bile duct dilations and ductal plate malformation disorders
Cystic fibrosis
Hereditary disorders of bile acid synthesis and bilirubin metabolism
Disorders of porphyrin metabolism
Disorders of carbohydrate metabolism and related conditions
Disorders of glycoprotein and glycolipid metabolism
Endoplasmic reticulum storage diseases
Disorders of amino acid metabolism
Disorders of lipoprotein and lipid metabolism
Peroxisomal disorders
Mitochondriopathies (mitochondrial cytopathies) and related conditions
Disorders of copper metabolism
Disorders of manganese metabolism
Primary immunodeficiencies
Histiocytic and haemophagocytic syndromes
Miscellaneous disorders
Anatomical anomalies
Chapter 4 Disorders of Iron Overload
Iron metabolism and homeostasis
Hereditary iron overload
Miscellaneous iron overload
Acquired/secondary iron overload
The role of the liver biopsy in iron overload
Chapter 5 Fatty Liver Disease
Spectrum of fatty liver disease
Alcohol-related liver disease
Pathology of alcohol-related liver disease
Diagnosis and prognosis of alcohol-related liver disease: role of liver biopsy
Treatment of alcohol-related liver disease and histopathological features of resolution
Nonalcoholic fatty liver disease
Pathology of nonalcoholic fatty liver disease
Differential diagnosis of nonalcoholic fatty liver disease
Nonalcoholic fatty liver and nonalcoholic steatohepatitis concurrent with other liver disease
Histopathological features of prognostic significance
Nonalcoholic fatty liver and nonalcoholic steatohepatitis in other clinical settings
Treatment of nonalcoholic fatty liver disease
Chapter 6 Hepatitis Due to Hepatotropic Viruses
Acute viral hepatitis
Chronic viral hepatitis
Individual types of viral hepatitis
Chapter 7 Non-Hepatotropic Viral, Bacterial and Parasitic Infections of the Liver
RNA viral infections
DNA viral infections
Rickettsial and chlamydial infections
Bacterial infections
Mycobacterial infections
Mycotic infections
Protozoal infections
Helminth infections
HIV infection and AIDS
Chapter 8 Autoimmune Hepatitis
Demographic features
Clinical features
Variant forms of cholestatic liver disease (‘overlap syndromes’)
Diagnostic difficulties
Role of liver biopsy
Chapter 9 Bile Duct Diseases
Normal morphology
Biliary epithelial injury
Classification of cholangiopathy and cholangitis
Immunological features of biliary diseases
Pathological features secondary to impaired bile flow
Diseases primarily affecting intrahepatic bile ducts
Diseases affecting extrahepatic and intrahepatic biliary tree
Diseases primarily affecting extrahepatic bile ducts
Pathology of the peribiliary glands
Chapter 10 Diseases of the Gallbladder
Normal gallbladder
Routine specimen processing
Congenital anomalies
Other inflammatory diseases of the gallbladder
Diverticular disease
Ischaemia and infarction
Non-neoplastic mucosal alterations
Non-neoplastic tumour-like lesions
Preinvasive epithelial neoplasia
Malignant neoplasms
Chapter 11 Vascular Disorders
Portal vein lesions
Hepatic artery-related lesions
Sinusoidal lesions
Hepatic vein lesions
Paediatric and developmental vascular lesions
Nodular hyperplastic lesions
Vascular lesions in cirrhosis
Chapter 12 Hepatic Injury due to Drugs, Dietary and Herbal Supplements, Chemicals and Toxins
Importance of drug-induced hepatic injury
Clinico-pathological-mechanistic classification of hepatotoxic agents
The morphological patterns of toxic hepatic injury
Clinical presentations and outcomes
Chemicals and environmental agents causing hepatic injury
Trinitrotoluene and other nitroaromatic and nitroaliphatic compounds
Hepatotoxic herbal remedies, dietary supplements and weight loss products
Liver disease due to medicinal agents
Diagnostic considerations in causality assessment of drug-induced liver injury
Treatment and prevention of drug-induced liver injury
Chapter 13 Tumours and Tumour-Like Lesions
Diagnostic approach: morphological patterns
Benign hepatocellular tumours and tumour-like lesions
Malignant hepatocellular tumours and precursor lesions
Biliary tumours and tumour-like lesions
Vascular tumours
Nonvascular mesenchymal tumours and tumour-like lesions
Other tumours and tumour-like lesions
Leukaemia and myeloproliferative disease
Lymphomas and lymphoreticular neoplasms
Metastatic tumours
Chapter 14 Transplantation Pathology
General aspects of liver transplantation
Examination of native hepatectomy specimens
Pathological changes in post-reperfusion biopsies of donor liver and bile duct and preservation/reperfusion injury
Liver allograft rejection
Vascular disorders
Biliary complications
Disease recurrence
De novo disease
Other histological findings in post-transplant biopsies
Drug toxicity in liver allograft recipients
Liver disease after haematopoietic cell (bone marrow and peripheral stem cell) transplantation
Chapter 15 Liver in Systemic Disease
Nonspecific reactive hepatitis
Space-occupying lesions in the liver
Hepatic granulomas
Nutritional liver disease
The liver in gastrointestinal diseases
The liver in pancreatic diseases
The liver in endocrine diseases
The liver in pregnancy
The liver in haematological diseases
The liver in connective tissue and joint diseases
The liver in renal diseases
The liver in amyloidosis and monoclonal immunoglobulin deposition disease
The liver in cardiovascular diseases
The liver and lung disease
Miscellaneous liver involvement in other diseases