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The Endocrine System, 3rd Edition. Systems of the Body Series

ISBN: 9780702083273
Διαστάσεις 24 × 19 cm



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The Systems of the Body series has established itself as a highly valuable resource for medical and other health science students following today’s systems-based courses. Now thoroughly revised and updated in this third edition, each volume presents the core knowledge of basic science and clinical conditions that medical students need, providing a concise, fully integrated view of each major body system that can be hard to find in more traditionally arranged textbooks or other resources. Multiple case studies help relate key principles to current practice, with links to clinical skills, clinical investigation and therapeutics made clear throughout.

Each (print) volume also now comes with access to the complete, enhanced eBook version, offering easy anytime, anywhere access – as well as self-assessment material to check your understanding and aid exam preparation.

The Endocrine System provides highly accessible coverage of the core basic science principles in the context of clinical case histories, giving the reader a fully integrated understanding of the system and its major diseases.

    • Introduction
    • Receptors and Hormone Action
    • The Hypothalamus and Pituitary Part I: The Hypothalamus and Posterior Pituitary4
    • The Hypothalamus and Pituitary Part II: The Anterior Pituitary
    • The Adrenal Glands Part I: The Adrenal Medulla
    • The Adrenal Glands Part II: The Adrenal Cortex
    • The Thyroid Gland
    • Hormonal Control of Reproduction Part I: Male Reproductive System
    • Hormonal Control of Reproduction Part II: Female Reproductive System
    • Hormonal Control of Reproduction Part III: Development and Fertility
    • Insulin and the Regulation of Plasma Glucose
    • Hormonal Regulation of Plasma Calcium and Calcium Metabolism
    • Miscellaneous Hormones

Systems of the Body Series:

    • The Renal System
    • The Musculoskeletal System
    • The Nervous System
    • The Digestive System
    • The Endocrine System
    • The Respiratory System
    • The Cardiovascular System
Author Information
By Joy P. Hinson Raven, BSc, PhD, DSc, FHEA, Professor of Endocrine Science, Dean for Postgraduate Studies, Bart’s and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Peter Raven, BSc PhD MBBS MRCP MRCPsych FHEA, Faculty Tutor (Biomedical Sciences), Faculty of Medical Sciences, University College London; Honorary Consultant Psychiatrist, Camden & Islington Mental Health Trust, London, UK and Shern L. Chew, BSc, MD, FRCP, Professor of Endocrine Medicine, Consultant Physician, Bart’s and the London School of Medicine and Dentistry, Queen Mary University, London, UK


  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Series Editor Foreword
  • Preface
  • Acknowledgements
  • Chapter 1. Introduction
  • Introduction
  • Important concepts in endocrine regulation
  • Hormone antagonism and synergy
  • Endocrine disorders
  • Endocrine investigations: general principles
  • Chapter 2. Receptors and hormone action
  • Introduction
  • General characteristics of receptors
  • Types of hormone receptors
  • Receptors that directly activate a protein kinase
  • Hormonal regulation of transcription
  • Disorders of receptor function
  • Chapter 3. The hypothalamus and pituitary part I: >The hypothalamus and posterior pituitary
  • Introduction
  • Where can I find the hypothalamus and pituitary?
  • Connection between the hypothalamus and pituitary
  • Development of the hypothalamus and pituitary
  • Release of posterior pituitary hormones is part of a neuroendocrine reflex: oxytocin secretion and actions
  • Regulation of vasopressin secretion
  • Disorders of vasopressin secretion and action
  • Other hypothalamic hormones
  • Chapter 4. The hypothalamus and pituitary part II: The anterior pituitary
  • Introduction
  • Structure of the anterior pituitary
  • The hormones of the anterior pituitary
  • Regulation of hormone secretion in the anterior pituitary
  • Actions of the anterior pituitary hormones: growth hormone and prolactin
  • Disorders of anterior pituitary function: oversecretion
  • Treatment of acromegaly
  • Disorders of undersecretion of anterior pituitary hormones
  • Tests for hypopituitarism
  • Chapter 5. The adrenal glands part I: The adrenal medulla
  • Introduction
  • Where to find the adrenal glands
  • Blood supply
  • Nerve supply
  • Embryology of the adrenal gland
  • The adrenal medulla
  • Disorders of the adrenal medulla: phaeochromocytoma
  • Pharmacological uses of hormones of the adrenal medulla
  • Endocrine hypertension
  • Chapter 6. The adrenal glands part II: The adrenal cortex
  • Introduction
  • Structure of the adrenal cortex
  • Hormones produced by the adrenal cortex
  • Regulation of steroid production
  • Transport of steroid hormones in blood
  • Disorders of adrenal steroids
  • Pharmacological uses of glucocorticoids
  • Chapter 7. The thyroid gland
  • Introduction
  • Thyroid anatomy
  • What is a goitre?
  • Blood supply
  • Structure of the thyroid
  • Synthesis of thyroid hormones
  • Iodine
  • Thyroxine and T3: the thyroid hormones in blood
  • Control of thyroid function
  • Cellular action of thyroid hormones
  • Effects of thyroid hormones
  • Disorders of thyroid hormone secretion
  • Causes of thyroid hyposecretion
  • Effects of thyroid hormone insufficiency in adults
  • Chapter 8. Hormonal control of reproduction part I: male reproductive system
  • Introduction
  • Where are the testes?
  • What are the testes?
  • Testicular blood and nerve supply
  • Spermatogenesis
  • Androgen production
  • Hormonal control of testicular function
  • Transport of testosterone in blood
  • Actions of testosterone
  • Hormone-dependent cancer in men
  • Disorders of male reproduction
  • Therapeutic uses of androgens
  • Abuse of anabolic androgenic steroids
  • Declining sperm counts
  • Chapter 9. Hormonal control of reproduction part II: Female reproductive system
  • Introduction
  • Structure of the ovary
  • Ovarian hormones
  • Transport and metabolism of oestrogen and progesterone
  • Oestrogens
  • Hormonal regulation of ovarian function
  • Hormone-dependent cancer in women
  • The menstrual cycle
  • Disorders of the menstrual cycle
  • The endocrinology of pregnancy
  • Chapter 10. Hormonal control of reproduction part III: Development and fertility
  • Introduction
  • Gender determination and differentiation
  • Hormonal control of sexual differentiation
  • Abnormalities of sexual differentiation
  • Hormones during development: puberty and menarche
  • Disorders of puberty
  • Menopause and the climacteric
  • Premature ovarian failure
  • Symptoms of the menopause
  • Hormone replacement therapy
  • Alternative therapies
  • Hormonal control of fertility: contraception
  • Hormonal control of fertility: assisted conception
  • Chapter 11. Insulin and the regulation of plasma glucose
  • Introduction
  • Sources of plasma glucose
  • Glucose in urine
  • Insulin and the response to high blood glucose levels
  • Disorders of blood glucose regulation: diabetes mellitus
  • Gestational diabetes
  • Metabolic syndrome – a growing problem?
  • Chapter 12. Hormonal regulation of plasma calcium and calcium metabolism
  • Introduction
  • Serum calcium
  • The structure, functions, and endocrinology of bone
  • Hormones involved in the regulation of serum calcium
  • Parathyroid hormone
  • Calcitriol: source and activation of vitamin D
  • Effects of other hormones on plasma calcium
  • Disorders of hypercalcaemia
  • Disorders of hypocalcaemia
  • Diseases of bone
  • A brief mention of calcitonin
  • Regulation of serum phosphate
  • Chapter 13. Miscellaneous hormones
  • Erythropoietin
  • Immune–endocrine interactions: cytokines and eicosanoids
  • Age-related changes in hormone secretion
  • Melatonin
  • Gut hormones
  • The hormonal control of appetite
  • Multiple organ disorders in endocrinology
  • Regulation of blood pressure and volume
  • The next 100 years of endocrinology
  • Glossary
  • Index