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The Netter Collection of Medical Illustrations: Nervous System, Volume 7, Part I – Brain, 3rd Edition

ISBN: 9780323880848



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Offering a concise, highly visual approach to the basic science and clinical pathology of the nervous system, this updated volume in The Netter Collection of Medical Illustrations (the CIBA “Green Books”) contains unparalleled didactic illustrations reflecting the latest medical knowledge. Revised by Drs. Michael J. Aminoff, Scott L. Pomeroy, and Kerry H. Levin, Brain, Part 1 of the Nervous System, Volume 7, integrates core concepts of anatomy, physiology, and other basic sciences with common clinical correlates across health, medical, and surgical disciplines. Classic Netter art, updated and new illustrations, and modern imaging continue to bring medical concepts to life and make this timeless work an essential resource for students, clinicians, and educators.
Key Features
  • Provides a highly visual guide to this complex organ, from basic neurodevelopment, neuroanatomy, neurophysiology, and cognition to a full range of disorders, including epilepsy, disorders of consciousness and sleep, movement disorders, stroke, multiple sclerosis, neurologic infections, neuro-oncology, headaches, and brain trauma.
  • Offers expanded coverage of timely topics like acute flaccid paralysis; neurological complications of COVID-19, ependymomas, genetics of epilepsy, and more.
  • Provides a concise overview of complex information by seamlessly integrating anatomical and physiological concepts using practical clinical scenarios.
  • Shares the experience and knowledge of Drs. Michael J. Aminoff, Scott L. Pomeroy, and Kerry H. Levin, with content overseen by experts at Harvard, UCSF, and other leading neurology centers.
  • Compiles Dr. Frank H. Netter’s master medical artistry—an aesthetic tribute and source of inspiration for medical professionals for over half a century—along with new art in the Netter tradition for each of the major body systems, making this volume a powerful and memorable tool for building foundational knowledge and educating patients or staff.
  • NEW! An eBook version is included with purchase. The eBook allows you to access all of the text, figures, and references, with the ability to search, make notes and highlights, and have content read aloud.


Cover image
Title page
Table of Contents
About the Series
About the Editors
In Memoriam
Preface, Acknowledgments, and Dedication
Foreword to the Second Edition
Frank Netter, MD: A Personal Recollection
Introduction to the First Edition—Part I
Contributors to Second Edition
Contents of Complete Volume 7—Nervous System: Two Part Set
1.  Normal and abnormal development
    Plate 1.1 Initial specification of the nervous system: The embryo at 18 days
    Plate 1.2 Initial formation of the brain and spinal cord: The embryo at 20 to 24 days
    Plates 1.3–1.4 Morphogenesis of the brain, spinal cord, and peripheral nervous system: The embryo from 28 through 36 days
    Plates 1.5–1.6 Defective neural tube formation
    Plates 1.7–1.8 Spinal dysraphism
    Plate 1.9 Fetal brain growth in the first trimester
    Plate 1.10 Craniosynostosis
    Plate 1.11 Extracranial hemorrhage and skull fractures in the newborn
    Plate 1.12 Intracranial hemorrhage in the newborn
    Plate 1.13 External development of the brain in the second and third trimesters
    Plate 1.14 Mature brain ventricles
    Plate 1.15 Hydrocephalus
    Plate 1.16 Surgical treatment of hydrocephalus
    Plate 1.17 Cerebral palsy
    Plate 1.18 Establishing cellular diversity in the embryonic brain and spinal cord
    Plate 1.19 Generation of neuronal diversity in the spinal cord and hindbrain
    Plate 1.20 Circuit formation in the spinal cord
    Plates 1.21–1.22 Making peripheral nerves and central tracts
    Plate 1.23 Brachial plexus and/or cervical nerve root injuries at birth
    Plate 1.24 Morphogenesis and regional differentiation of the forebrain
    Plate 1.25 Neurogenesis and cell migration in the developing neocortex
    Plate 1.26 Neuronal proliferation and migration disorders
    Plate 1.27 Developmental dyslexia
    Plate 1.28 Autism spectrum disorder
    Plates 1.29–1.30 Rett syndrome
2.  Cerebral cortex and neurocognitive disorders
    Plates 2.1–2.3 Surfaces of the cerebrum
    Plate 2.4 Cerebral cortex: Function and association pathways
    Plate 2.5 Major cortical association bundles
    Plate 2.6 Corticocortical and subcorticocortical projection circuits
    Plate 2.7 Corpus callosum
    Plate 2.8 Rhinencephalon and limbic system
    Plate 2.9 Hippocampus
    Plate 2.10 Fornix
    Plate 2.11 Amygdala
    Plate 2.12 Forebrain regions associated with hypothalamus
    Plate 2.13 Thalamocortical radiations
    Plate 2.14 Neuronal structure and synapses
    Plate 2.15 Chemical synaptic transmission
    Plate 2.16 Summation of excitation and inhibition
    Plate 2.17 Types of neurons in cerebral cortex
    Plate 2.18 Astrocytes
    Plate 2.19 Testing for defects of higher cortical function
    Plate 2.20 Memory circuits
    Plate 2.21 Amnesia
    Plate 2.22 Dominant hemisphere language dysfunction
    Plate 2.23 Nondominant hemisphere higher cortical dysfunction
    Plate 2.24 Alzheimer disease: Pathology
    Plate 2.25 Alzheimer disease: Distribution of pathology
    Plate 2.26 Alzheimer disease: Clinical manifestations, progressive phases
    Plate 2.27 Frontotemporal dementia
    Plate 2.28 Dementia with lewy bodies
    Plate 2.29 Vascular dementia
    Plate 2.30 Treatable dementias
    Plate 2.31 Normal-pressure hydrocephalus
3.  Epilepsy
    Plate 3.1 Electroencephalography
    Plates 3.2–3.4 Seizures and epilepsy
    Plate 3.5 Epilepsy syndromes
    Plate 3.6 Neonatal seizures
    Plate 3.7 Status epilepticus
    Plate 3.8 Causes of seizures
    Plates 3.9–3.11 Neurobiology of epilepsy
    Plates 3.12–3.13 Treatment of epilepsy
4.  Psychiatry
    Plate 4.1 Limbic system
    Plate 4.2 Major depressive disorder
    Plate 4.3 Postpartum depression
    Plates 4.4–4.5 Bipolar disorder
    Plate 4.6 Generalized anxiety disorder
    Plate 4.7 Social anxiety disorder
    Plate 4.8 Panic disorder
    Plate 4.9 Posttraumatic stress disorder
    Plate 4.10 Obsessive-compulsive disorder
    Plate 4.11 Somatization
    Plate 4.12 Conversion disorder
    Plate 4.13 Schizophrenia
    Plate 4.14 Alcohol use disorder
    Plate 4.15 Treatment for alcohol use disorder
    Plate 4.16 Alcohol withdrawal
    Plates 4.17–4.18 Opioid use disorders
    Plate 4.19 Opioid withdrawal
    Plate 4.20 Borderline personality disorder
    Plate 4.21 Antisocial personality disorder
    Plate 4.22 Intimate partner violence
    Plate 4.23 Abuse in later life
    Plates 4.24–4.25 Delirium and acute personality changes
    Plate 4.26 Insomnia
    Plate 4.27 Pediatrics: Depressive disorders
    Plate 4.28 Pediatrics: Anxiety disorders
    Plate 4.29 Pediatrics: Disruptive behavior disorders
    Plate 4.30 Pediatrics: Attention-deficit/hyperactivity disorders
    Plate 4.31 Pediatrics: Eating and feeding disorders
    Plates 4.32–4.33 Child abuse
5.  Hypothalamus, pituitary, sleep, and thalamus
    Plate 5.1 Anatomic relationships of the hypothalamus
    Plate 5.2 Development and developmental disorders of the hypothalamus
    Plate 5.3 Blood supply of the hypothalamus and pituitary gland
    Plates 5.4–5.5 Overview of hypothalamic cell groups
    Plate 5.6 Hypothalamic control of the pituitary gland
    Plate 5.7 Hypothalamic control of the autonomic nervous system
    Plate 5.8 Olfactory inputs to the hypothalamus
    Plate 5.9 Visual inputs to the hypothalamus
    Plate 5.10 Somatosensory inputs to the hypothalamus
    Plate 5.11 Taste and other visceral sensory inputs to the hypothalamus
    Plate 5.12 Limbic and cortical inputs to the hypothalamus
    Plate 5.13 Overview of hypothalamic function and dysfunction
    Plate 5.14 Regulation of water balance
    Plate 5.15 Temperature regulation
    Plates 5.16–5.17 Fever and the hypothalamic sickness response to systemic inflammation
    Plate 5.18 Regulation of food intake, body weight, and metabolism
    Plate 5.19 Stress response
    Plate 5.20 Hypothalamic regulation of cardiovascular function
    Plate 5.21 Hypothalamic regulation of sleep
    Plate 5.22 Narcolepsy: A hypothalamic sleep disorder
    Plate 5.23 Sleep-disordered breathing
    Plate 5.24 Parasomnias
    Plate 5.25 Divisions of the pituitary gland and its relationships to the hypothalamus
    Plate 5.26 Posterior pituitary gland
    Plate 5.27 Anatomic relationships of the pituitary gland
    Plate 5.28 Effects of pituitary mass lesions on the visual apparatus
    Plate 5.29 Anterior pituitary hormone deficiencies
    Plate 5.30 Severe anterior and posterior pituitary hormone deficiencies (panhypopituitarism)
    Plate 5.31 Postpartum pituitary infarction (sheehan syndrome)
    Plate 5.32 Pituitary apoplexy
    Plates 5.33–5.34 Thalamic anatomy and pathology
6.  Disorders of consciousness (coma)
    Plate 6.1 Coma
    Plate 6.2 Disorders of consciousness
    Plates 6.3–6.4 Emergency management and assessment and neurologic examination
    Plate 6.5 Differential diagnosis of coma
    Plate 6.6 Hypoxic-ischemic brain damage
    Plate 6.7 Vegetative state, minimally conscious state, and unresponsive wakefulness syndrome
    Plate 6.8 Brain death or death by neurologic criteria
    Plate 6.9 Ventilatory patterns and the apnea test
7.  Basal ganglia and movement disorders
    Plates 7.1–7.3 Anatomy of the basal ganglia and related structures
    Plates 7.4–7.10 Akinetic-rigid syndrome, parkinsonism, or parkinsonian syndrome
    Plates 7.11–7.16 Hyperkinetic movement disorders
    Plate 7.17 Wilson disease
    Plate 7.18 Psychogenic movement disorders
    Plate 7.19 Cerebral palsy
8.  Cerebellum and ataxia
    Plate 8.1 Cerebellum and the fourth ventricle
    Plate 8.2 Cerebellum gross anatomy
    Plate 8.3 Cerebellar peduncles
    Plates 8.4–8.5 Cerebellar cortex and nuclei
    Plates 8.6–8.7 Cerebellar cortical and corticonuclear circuitry
    Plates 8.8–8.9 Cerebellum subdivisions and afferent pathways
    Plate 8.10 Cerebellar efferent pathways
    Plate 8.11 Cerebellovestibular pathways
    Plate 8.12 Cerebellum modular organization
    Plate 8.13 Cerebrocerebellar connections
    Plate 8.14 Cerebellar motor examination
    Plate 8.15 Cerebellar cognitive affective syndrome
    Plate 8.16 Cerebellar disorders: Differential diagnosis
    Plates 8.17–8.18 Gait disorders: Differential diagnosis
    Plates 8.19–8.20 Friedreich ataxia
9.  Cerebrovascular circulation and stroke
    Plates 9.1–9.6 Arterial supply to the brain and meninges
    Plates 9.7–9.8 Types of stroke
    Plates 9.9–9.10 Clinical evaluation and treatment of stroke
    Plate 9.11 Uncommon etiologic mechanisms of stroke
    Plates 9.12–9.19 Anterior circulation ischemia
    Plates 9.20–9.25 Vertebral basilar system disorders
    Plates 9.26–9.27 Brain emboli
    Plates 9.28–9.29 Lacunar stroke
    Plate 9.30 Hypertensive encephalopathy
    Plate 9.31 Hypoxia
    Plates 9.32–9.34 Coagulopathies
    Plates 9.35–9.37 Venous sinus thrombosis
    Plates 9.38–9.40 Intracerebral hemorrhage
    Plates 9.41–9.45 Intracranial aneurysms and subarachnoid hemorrhage
    Plate 9.46 Pediatric cerebrovascular disease
    Plate 9.47 Introduction and initial stroke rehabilitation
    Plate 9.48 Aphasia rehabilitation
    Plate 9.49 Other rehabilitative issues: Gait training, upper limb dysfunction, locked-in syndrome
    Plate 9.50 Other rehabilitative issues: Dysphagia
10.  Multiple sclerosis and other central nervous system autoimmune disorders
    Plate 10.1 Multiple sclerosis: Overview
    Plate 10.2 Multiple sclerosis: Clinical manifestations
    Plates 10.3–10.5 Multiple sclerosis: Diagnosis
    Plates 10.6–10.7 Multiple sclerosis: Pathophysiology
    Plates 10.8–10.11 Multiple sclerosis: Relapses
    Plate 10.12 Enigma of progressive multiple sclerosis
    Plate 10.13 Multiple sclerosis: Pathology
    Plate 10.14 Multiple sclerosis: Treatment
    Plates 10.15–10.16 Neuromyelitis optica spectrum disorder, mogad, and acute disseminated encephalomyelitis
    Plate 10.17 Introduction to autoimmune neurologic syndromes
    Plate 10.18 Stiff person syndrome spectrum disorder
    Plates 10.19–10.20 Autoimmune and paraneoplastic neurologic syndromes
    Plates 10.21–10.22 Autoimmune neurologic syndromes: Central and peripheral nervous system manifestations
11.  Infections of the nervous system
    Plates 11.1–11.2 Bacterial meningitis
    Plate 11.3 Brain abscess
    Plate 11.4 Parameningeal infections
    Plates 11.5–11.6 Infections in the immunocompromised host
    Plate 11.7 Neurocysticercosis
    Plate 11.8 Spirochetal infections: Neurosyphilis
    Plate 11.9 Spirochetal infections: Lyme disease
    Plate 11.10 Tuberculosis of brain and spine
    Plate 11.11 Tetanus
    Plate 11.12 Aseptic meningitis and select arthropod-borne virus infections
    Plates 11.13–11.14 Human immunodeficiency virus
    Plate 11.15 Poliomyelitis
    Plate 11.16 Acute flaccid paralysis
    Plate 11.17 Herpes zoster
    Plate 11.18 Herpes simplex virus encephalitis and rabies
    Plate 11.19 Parasitic infections: Cerebral malaria and african trypanosomiasis
    Plate 11.20 Parasitic infections: Trichinosis (trichinellosis)
    Plate 11.21 Parasitic infections: Cryptococcal meningitis
    Plate 11.22 Creutzfeldt-jakob disease
    Plate 11.23 Neurosarcoidosis
    Plate 11.24 Neurologic complications of COVID-19
12.  Neuro-oncology
    Plate 12.1 Clinical presentations of brain tumors
    Plate 12.2 2021 WHO changes to classification of central nervous system tumors
    Plate 12.3 Gliomas
    Plate 12.4 Glioblastomas
    Plates 12.5–12.6 Pediatric brain tumors
    Plate 12.7 Ependymomas
    Plate 12.8 Metastatic tumors to brain
    Plates 12.9–12.10 Meningiomas
    Plates 12.11–12.13 Pituitary tumors and craniopharyngiomas
    Plate 12.14 Tumors of pineal region
    Plates 12.15–12.16 Vestibular schwannomas
    Plate 12.17 Intraventricular tumors
    Plate 12.18 Chordomas
    Plate 12.19 Differential diagnosis of central nervous system tumors
    Plates 12.20–12.21 Spinal tumors
    Plate 12.22 Treatment modalities
13.  Headache
    Plate 13.1 Overview of headaches
    Plate 13.2 Migraine pathophysiology
    Plate 13.3 Migraine presentation
    Plate 13.4 Migraine aura
    Plate 13.5 Migraine management
    Plates 13.6–13.7 Trigeminal autonomic cephalalgias
    Plate 13.8 Tension-type headache and other benign episodic and chronic headaches
    Plate 13.9 Pediatric headache
    Plate 13.10 Cranial neuralgias: Trigeminal neuralgia
    Plate 13.11 Other cranial neuralgias
    Plate 13.12 Idiopathic intracranial hypertension
    Plate 13.13 Intracranial hypotension/low CSF pressure headache
    Plate 13.14 Giant cell arteritis
    Plate 13.15 Contiguous structure headaches
    Plates 13.16–13.19 Thunderclap headache and other headache presenting in the emergency department
14.  Head trauma
    Plates 14.1–14.2 Skull: Anterior and lateral aspects
    Plate 14.3 Skull: Midsagittal section
    Plate 14.4 Calvaria
    Plate 14.5 External aspect of skull base
    Plates 14.6–14.7 Bones, markings, and orifices of skull base
    Plate 14.8 Skull injuries
    Plate 14.9 Concussion
    Plate 14.10 Acute epidural hematoma
    Plate 14.11 Acute subdural hematoma
    Plate 14.12 CT scans and magnetic resonance images of intracranial hematomas
    Plate 14.13 Vascular injury
    Plate 14.14 Glasgow coma scale score
    Plate 14.15 Initial assessment and management of head injury
    Plates 14.16–14.17 Neurocritical care and management after traumatic brain injury
Selected references