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Need-to-Know NAFLD. The Complete Guide to Nonalcoholic Fatty Liver Disease 1st Edition

ISBN: 9781032479484
ISBN: 9781032479484
Διαστάσεις 28 × 21 cm



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Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the obesity and metabolic syndrome epidemics, which this up-to-date book deals with comprehensively. The contents outline disease mechanisms, diagnostic tests, management, varying manifestations, and special populations. It covers the mechanistic pathways that contribute to NAFLD development, including the role of genetic variants and the gut microbiome. It elaborates on noninvasive diagnostic tests to screen for NAFLD, determine its severity, and monitor response to lifestyle intervention and pharmacologic treatment. This book helps clinicians diagnose and treat this common and potentially deadly disease.

Key Features:

  • Reviews current drugs in development and provides practical advice to clinicians on the diagnosis and management of fatty liver.
  • Proves attractive to primary care providers who are on the front line of managing patients with NAFLD, to gastroenterologists and hepatologists who would benefit from updated data on how to risk-stratify patients and identify those who will be eligible for pharmacologic treatment, and other specialists such as cardiologists, endocrinologists, and nephrologists who will find this book to be a useful reference on the extrahepatic manifestations of NAFLD.
  • Focuses on extrahepatic manifestations and new insights on the mechanistic drivers of the disease.


Preface – Naim Alkhouri and Stephen A Harrison


Section 1. Mechanisms of NAFLD Development

1.Historical Perspectives and Clinical Presentation – Imad Asaad, Naim Alkouri

2.Epidemiology and Natural History of Non-Alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis – Linda Henry, Zobair M Younossi

3.Genetics of NAFLD – Luca Valenti, Cristiana Bianco

4.Mechanisms of hepatocyte injury and inflammation in NAFLD – Gopanandan Parthasarathy, Harmeet Malhi

5.The role of the microbiome – Carlos J Pirola and Silvia Sookoian


Section 2. Diagnostic Tests

6.Simple Algorithms in Primary Care – Xixi Xu, and Michelle T. Long

7.Ultrasound based techniques in NAFLD – Vikas Taneja, Nezam H Afdhal, and Michelle J Lai

8.MRI-based technologies – Victor de Lédinghen

9.Artificial intelligence in NAFLD diagnosis – Joseph C. Ahn, and Samer Gawrieh


Section 3. Management

10.Dietary interventions – Monica Tincopa

11.Weight Loss Medications – Mohammad Qasim Khan, Manhal Izzy, Kymberly D. Watt

12.De novo lipogenesis inhibitors – Brent A. Neuschwander-Tetri

13.Targeting bile acids (FXRs and FGF19) – Daniel Garrido, Rukaiya Bashir Hamidu, Dina Halegoua-DeMarzio

14.PPAR agonists – Sven MA Francque

15.Anti-inflammatory drugs: Metabolic inflammation in NASH as a therapeutic target – Angelo Armandi, Jörn M. Schattenberg

16.Practical Aspects of Pharmacologic Management – Naim Alkhouri and Stephen A. Harrison


Section 4. Extrahepatic Manifestations

17.Endocrinology: Diabetes and other endocrinopathies – Scott Isaacs, Julio Leey

18.Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease – Dania Brigham and Shikha S. Sundaram

19.Extrahepatic Gastrointestinal Manifestations of Non-alcoholic Fatty Liver Disease – Rinjal Brahmbhatt, Mousab Tabbaa

20.Extrahepatic and Hepatic cancers – Maryam Ibrahim, Tracey G. Simon


Section 5. NAFLD in special populations

21.NAFLD in Children: Unique Aspects and Controversies – Samar H Ibrahim, Rohit Kohli

22.NAFLD in HIV patients – Giada Sebastiani

23.NAFLD in Liver Transplant Recipients – Liyun Yuan and Norah Terrault

24.NAFLD in lean individuals – Donghee Kim and Vincent Wai-Sun Wong