An accessible introduction to RNA viruses and the infectious outcomes that they cause in the central nervous system. Including the major RNA viruses, their impact on the central nervous system (CNS), and the similarities and differences in pathological outcomes that can be observed. Neuroscientists be they students, researchers, and clinicians will benefit from the up to date and timely coverage provided.
Our understanding of viruses, and specifically RNA viruses and their pathological impact, is rapidly evolving. For example, the close molecular interaction of viruses with the CNS cell types in the human host is poorly understood. Readers will be able to use the book to clearly understand the cellular and molecular mechanisms governing pathological outcomes of RNA virus infection in the cell types of human brain (e.g., neurons, endothelial cells, astrocytes, resident immune cells) based on summarized case studies, and gain insight into how cell-type specific defects affects the brain function and causes poor clinical outcomes.
Aimed primarily at neuroscience students and postgraduates wishing to learn about virology as well as professionals who are interested to learn more about virus-associated neuropathology. A basic knowledge of cell and molecular biology is assumed, however readers across the disciplines of science, technology, engineering, and mathematics (STEM) will find this topical and timely publication of value.
Chapter 1: Structure and Classification of RNA viruses Amal Senevirathne Chapter 2: RNA viruses with CNS tropism Amrit Varsha Chapter 3: Common Neuropathological features of RNA viruses Anne Khodarkovskaya Chapter 4: Molecular and cellular alterations underlying neurological outcomes in HIV infection Sabyasachi Dash Chapter 5: Zika virus and CNS Reshma Bhagat Chapter 6: Neuropathological outcomes in human influenza and respiratory syncytial virus infections Sabyasachi Dash Chapter 7: The vascular route as a possible gateway for central nervous system pathology in SARS-CoV-2 infection Sabyasachi Dash and Anne Khodarkovskaya Chapter 8: Mechanisms for entry of RNA viruses into the CNS Reshma Bhagat Chapter 9: RNA sequencing as a powerful tool to capture virus-induced changes Conor J. Cremin Chapter 10: Novel methods and technologies for efficient detection of RNA viruses in the human brain Sukh Sandan, Ridhika Bangotra, Parveen Kumar, Neha Goel, Mohit Sharma Chapter 11: An insight into the symptomatic treatment modalities for COVID -19 Gifty Sawhney, Parveen Kumar, Suraj P Parihar, Mohit Sharma Chapter 12: Innovations in RNA therapeutics and sequencing technology to combat future viral pandemics Snehasmita Jena, Sudakshya Sucharita Lenka, Shaikh Sheeran Naser, Apoorv Kirti, Suresh K. Verma, Mrutyunjay Suar Chapter 13: Innovative Therepeutic Efforts for Tackling Future Viral Pandemics Umme Abiha , Nandan Patel , Neha Goel, Mohit Sharma