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Textbook of Ion Channels Three Volume Set

SKU: 9781032424309
ISBN: 9781032424309
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Περιγραφή

The Textbook of Ion Channels is a set of three volumes providing a wide-ranging reference source on ion channels for students, instructors, and researchers. Ion channels are membrane proteins that control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli like light, sound, odor, and taste, and regulate the response to physical stimuli like temperature and pressure. In non-excitable tissues, ion channels are instrumental for the regulation of basic salt balance that is critical for homeostasis. Ion channels are located at the surface membrane of cells, giving them the unique ability to communicate with the environment, as well as the membrane of intracellular organelles, allowing them to regulate internal homeostasis. Ion channels are fundamentally important for human health and diseases, and are important targets for pharmaceuticals in mental illness, heart disease, anesthesia, pain and other clinical applications. The modern methods used in their study are powerful and diverse, ranging from single ion-channel measurement techniques to models of ion channel diseases in animals, and human clinical trials for ion channel drugs.

All three volumes give the reader an introduction to fundamental concepts needed to understand the mechanism of ion channels, a guide to the technical aspects of ion channel research, offer a modern guide to the properties of major ion channel families, and include coverage of key examples of regulatory, physiological, and disease roles for ion channels.

Περιεχόμενα

Volume I

Chapter 1: Ion Selectivity and Conductance
Alexander A. Simon, Chen Fan, Dorothy M. Kim, Jason G. McCoy, Crina M. Nimigean

Chapter 2: Voltage-Dependent Gating of Ion Channels
Baron Chanda, Sandipan Chowdhury

Chapter 3: Ligand-Dependent Gating Mechanism
William N. Zagotta

Chapter 4: Mechanosensitive Channels and Their Emerging Gating Mechanisms
Sergei Sukharev, Andriy Anishkin

Chapter 5: Inactivation and Desensitization
William N. Zagotta

Chapter 6: Ion Channel Inhibitors
Matthew J. Marquis, Jon T. Sack

Chapter 7: Expression of Channels in Heterologous Systems and Voltage Clamp Recordings of Macroscopic Currents
Victor De la Rosa, León D. Islas

Chapter 8: Patch Clamping and Single-Channel Analysis
León D. Islas

Chapter 9: Patch Clamp Recordings from Native Cells and Isolation of Membrane Currents
Jeanne Nerbonne

Chapter 10: Models of Ion Channel Gating
Frank T. Horrigan, Toshinori Hoshi

Chapter 11: Investigating Ion Channel Structure and Dynamics Using Fluorescence Spectroscopy
Rikard Blunck

Chapter 12: Ion Channel Structural Biology in the Era of Single Particle Cryo-EM
Jianhua Zhao, Yifan Cheng

Chapter 13: Protein Crystallography
Moshe Giladi, Yoni Haitin

Chapter 14: Rosetta Structural Modeling
Phuong T. Nguyen, Vladimir Yarov-Yarovoy

Chapter 15: Molecular Dynamics
Lucie Delemotte

Chapter 16: Genetic Models and Transgenics
Andrea L. Meredith

Chapter 17: EPR and DEER Spectroscopy
Eric G. B. Evans, Stefan Stoll

Volume II

Chapter 1: Taxonomy and Evolution of Ion Channels
Timothy Jegla, Benjamin T. Simonson

Chapter 2: Voltage-Gated Sodium Channels
William A. Catterall

Chapter 3: Voltage-Gated Calcium Channels
Jacqueline Niu, Henry M. Colecraft

Chapter 4: Voltage-Gated Potassium Channels
Francis I. Valiyaveetil 

Chapter 5: ERG Family of K Channels
Sara Codding, Matthew C. Trudeau

Chapter 6: KCNQ Channels
H. Peter Larsson

Chapter 7: BK Channels
Jianmin Cui

Chapter 8: Small-Conductance Calcium-Activated Potassium (SK) Channels
Miao Zhang, Heike Wulff

Chapter 9: Inward Rectifier Potassium Channels
Camden Driggers, Min-Woo Sung, Show-Ling Shyng

Chapter 10: Two-Pore Domain Potassium Channels
Leigh D. Plant, Steve A. N. Goldstein

Chapter 11: Cyclic Nucleotide-Gated Channels
Michael D. Varnum

Chapter 12: HCN Channels
Colin H. Peters, Catherine Proenza

Chapter 13: CLC Chloride Channels and Transporters
Anna K. Koster, Merritt Maduke

Chapter 14: Ca-Activated Cl- Channels
Criss Hartzell

Chapter 15: Acetylcholine Receptors
Cecilia Bouzat, Juan Facundo Chrestia

Chapter 16: Ionotropic Glutamate Receptors
Andrew Plested

Chapter 17: 5-HT3 Receptors
Susanne M. Mesoy, Sarah C. R. Lummis

Chapter 18: GABAA Receptors
Trevor G. Smart

Chapter 19: Glycine Receptors
Josip Ivica, Lucia Sivilotti

Chapter 20: Acid Sensing Ion Channels
Yangyu Wu, Cecilia M. Canessa

Chapter 21: ENaC Channels
Mike Althaus, Diego Alvarez de la Rosa, Martin Fronius

Chapter 22: TRPC Channels
Jin Bin Tian, Michael X. Zhu

Chapter 23: TRPM Channels
David D. McKemy

Chapter 24: TRPV Channels
Tamara Rosenbaum

Chapter 25: Store-Operated CRAC Channels
Murali Prakriya

Chapter 26: Piezo Channels
Jörg Grandl, Bailong Xiao

Chapter 27: Ryanodine Receptors
Jean-Pierre Benitah, Laetitia Pereira, Liheng Yin, Jean-Jacques Mercadier, Marine Gandon-Renard, Almudena Val-Blasco, Romain Perrier, A. M. Gomez

Chapter 28: Proton Channels
Emily R. Liman, I. Scott Ramsey

Chapter 29: P2X Receptors
Kate Dunning, Thomas Grutter

Volume III

Chapter 1: Alternative Splicing
Andrea L. Meredith

Chapter 2: Calmodulin Regulation of Ion Channels
Ivy Dick, David T. Yue, Manu Ben-Johny

Chapter 3: Mechanism of G-protein Regulation of Ion Channels
Kirin D. Gada, Rahul Mahajan, Diomedes E. Logothetis

Chapter 4: Regulation of Ion Channels by Membrane Lipids
Tibor Rohacs

Chapter 5: Ion Channels of the Heart
Donald M. Bers, Eleonora Grandi

Chapter 6: Ion Channels in Sperm and Eggs
Rachel E. Bainbridge, Anne E. Carlson

Chapter 7: Ion Channels in Immune Cells
Michael D. Cahalan, Thomas E. DeCoursey

Chapter 8: Ion Channels in Epilepsy
Jeffrey L. Noebels

Chapter 9: Ion Channels in Pain
Richard Dean, J. P. Johnson

Chapter 10: Cystic Fibrosis and the CFTR Anion Channels
Han-I Yeh, Tzyh-Chang Hwang

Chapter 11: CLC-Related Proteins in Diseases
Allan H. Bretag, Linlin Ma, Deanne H. Hryciw

Chapter 12: KATP Channels and the Regulation of Insulin Secretion
Mike Puljung