Availability: In Stock

Textbook of SARS-CoV-2 and COVID-19, 1st Edition

ISBN: 9780323875394
ISBN: 9780323875394
Διαστάσεις 28 × 22 cm



Ημ. Έκδοσης





1η έκδοση


Κύριος Συγγραφέας

109,00(Περιλαμβάνεται ΦΠΑ 6%)

Διαθεσιμότητα: 11-14 ημέρες


Written by physicians and scientists with expertise in this evolving area, Textbook of SARS-CoV-2 and COVID-19 provides a coherent, readable, and clinically relevant review of the biology, epidemiology, pathophysiology, immunology, clinical features, current treatment, and prevention strategies for the SARS-CoV-2 virus. Using both a systemic and topic-based approach, it summarizes and clarifies the extensive literature published on SARS-CoV-2 and COVID-19, includes a comprehensive bibliography, and provides answers to clinical questions at the point of care from multiple specialty perspectives.
Key Features
  • Includes dedicated chapters for pulmonary, cardiac, neurological, and oral manifestations of COVID-19.
  • Covers therapeutics and novel therapeutic targets of SARS-CoV-2 and COVID-19.
  • Addresses the diagnostic and management challenges of COVID-19 in the emergency department.
  • Discusses COVID-19 in special populations, including the effect of SARS-CoV-2 infection in pregnant mothers and to the fetus and newborn.
  • Provides a systematic overview and comparison of vaccines that are approved and in development.
  • Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Author Information
By Subramani Mani, MBBS (MD), PhD, Independent research consultant; Former Associate Professor, Department of Medicine, University of New Mexico School of Medicine; Former Assistant Professor, Department of Biomedical Informatics, Vanderbilt University, Franklin, Tennessee and Jorn-Hendrik Weitkamp, MD, Associate Professor of Pediatrics, Monroe Carrell Jr. Children’s Hospital, Vanderbilt University Medical Center, Nashville, Tennessee


  • Cover Image
  • Title Page
  • Copyright
  • Dedication
  • Contributors
  • Acknowledgments
  • Preface
  • Table of Contents
  • Part I The Basics: Epidemiology, Biology, Pathogenesis, Immunology, and Natural History
  • Chapter 1 Epidemiology of SARS-CoV-2 and COVID-19
  • Outline
  • Asia
  • Europe
  • Americas
  • Africa
  • Oceania
  • Risk Factors for COVID-19
  • Conclusion
  • References
  • Chapter 2 SARS-CoV-2: Structure, Pathogenesis, and Diagnosis
  • Outline
  • SARS-CoV-2 and Coronaviruses
  • Structural Proteins
  • Accessory Proteins
  • Nonstructural Proteins
  • Mechanisms of SARS-CoV-2 Pathogenesis
  • Testing for Present and Past Infection
  • Conclusion
  • Acknowledgments
  • References
  • Chapter 3 Immunology of COVID-19
  • Outline
  • Innate Immune Responses
  • Adaptive Immune Responses
  • Immune Dysregulation and Immunopathology
  • The Global Pandemic and Questions for Future Research
  • Conclusion
  • Acknowledgments
  • References
  • Chapter 4 COVID-19: Natural History and Spectrum of Disease
  • Outline
  • Short Comparison of SARS-CoV-2 With SARS-CoV-1 and MERS-CoV
  • Natural History
  • Spectrum of COVID-19
  • Pathogenesis
  • Clinical Characteristics
  • Impact of Comorbidities
  • Radiology and Laboratory Features
  • Treatment, Clinical Course, and Outcomes
  • Drug Pipeline
  • Vaccines
  • Children and COVID-19
  • Post Recovery Symptoms and the Long-Hauler Syndrome
  • Racial Disparities in Susceptibility to SARS-CoV-2
  • Conclusion
  • References
  • Part II The Clinical: Manifestations in Systems and Domains of the Body
  • Chapter 5 Pulmonary Manifestations of COVID-19
  • COVID-19 Manifestations in the Respiratory System
  • Treatment and Management of Salient Pulmonary Manifestations and Complications of COVID-19
  • Management of Respiratory Failure
  • Current Guidelines and Medications Available for Management of COVID-19
  • General Principles of Management of Long-Term Pulmonary Sequelae
  • Case Reports Highlighting the Varied Pulmonary Manifestations of COVID-19
  • References
  • Chapter 6 COVID-19 and the Cardiovascular System
  • Epidemiology of Cardiac Injury From COVID-19
  • History of Cardiovascular Effects From SARS-CoV-1 and MERS-CoV
  • Pathophysiology and Potential Mechanisms of Cardiovascular Injury From COVID-19
  • Clinical Manifestations and Complications
  • Cardiovascular Comorbidities and COVID-19
  • Management of COVID-19–Related Cardiac Complications
  • Case Reports
  • COVID-19–Induced Cardiac Complications and Long-Term Sequelae
  • Conclusion
  • References
  • Chapter 7 Neurological Manifestations of COVID-19
  • Outline
  • Epidemiology of Neurological Manifestations of COVID-19
  • Historical Background of Neurological Effects of the Coronavirus Family
  • Pathophysiology, Pathogenesis, and Proposed Mechanisms of the SARS-CoV-2 Virus and the Nervous System
  • COVID-19 and the Peripheral Nervous System
  • COVID-19 and the Central Nervous System
  • Long COVID and Neurological Postacute Sequelae of SARS-CoV-2 Infection
  • COVID 19 and Challenges
  • Summary
  • References
  • Chapter 8 Oral Cavity and COVID-19: Clinical Manifestations, Pathology, and Dental Profession
  • Outline
  • The Oral Cavity and Viral Infections
  • SARS-CoV-2 and the Oral Cavity
  • Mechanisms of Oral Manifestations of SARS-CoV-2
  • The Oral Microbiome and COVID-19
  • Salivary Diagnostics, Transmission, and Biomarkers for COVID-19
  • SARS-CoV-2 and the Dental Office
  • Conclusion
  • References
  • Chapter 9 Gastrointestinal Manifestations of COVID-19
  • Outline
  • Prevalence of Gastrointestinal Symptoms
  • Implications of Gastrointestinal Symptoms in COVID-19
  • Mechanism on How SARS-CoV-2 Affects Gut Health
  • Impact of Gastric Acid Reduction on COVID-19 Outcomes
  • Impact of COVID-19 in Inflammatory Bowel Disease
  • Impact of COVID-19 on Liver
  • Impact of COVID-19 on Pancreatic Disorders
  • Association Between Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Use and Gastrointestinal Symptoms in COVID-19
  • Postinfectious Gastrointestinal Symptoms
  • Conclusion
  • References
  • Chapter 10 Kidney Manifestations of COVID-19
  • Outline
  • Acute Kidney Injury Incidence and Mortality Associated With SARS-CoV-2 Infection
  • Could Viral Tropism in Kidney Parenchyma Be Responsible for Acute Kidney Injury?
  • Tubular Injury in COVID-19
  • Glomerular Disease and COVID-19
  • COVID-19–Associated Nephropathy
  • Reports of Other Glomerulonephritis
  • Thrombotic Microangiopathy
  • Proposed Mechanisms
  • Management of COVID-19 Acute Kidney Injury
  • Medication Treatment
  • Renal Replacement Therapy
  • Unique Kidney Populations and COVID-19
  • End-Stage Kidney Disease and COVID-19
  • Transplant and COVID-19
  • Mortality of COVID-19 Infection in Kidney Transplant
  • Impact on Kidney Transplantation and Medication Management
  • Conclusion
  • References
  • Chapter 11 Ophthalmic Manifestations of COVID-19
  • Outline
  • Introduction and Historical Perspectives
  • Role of the Eye in Transmission and Prevention
  • Ocular Manifestations
  • Conclusion
  • References
  • Chapter 12 Psychiatric Manifestations of COVID-19
  • Outline
  • Introduction
  • Delirium
  • Impact of Preexisting Psychiatric Disorders on COVID-19 Outcomes
  • Anxiety, Depression, Mania, and Suicide Risk
  • Posttraumatic Stress Disorder and Trauma-Related Symptoms
  • Psychosis and Catatonia
  • Psychiatric Symptoms Directly Linked to Viral Infection
  • Conclusion
  • References
  • Part III Fetus, Newborn, Infants, Children
  • Chapter 13 Impact of Maternal SARS-CoV-2 Infection on the Fetus and Newborn
  • Outline
  • History of Perinatal Coronavirus Infections
  • Impacts of SARS-CoV-2 Infection on the Pregnant Mother
  • Impact of SARS-CoV-2 Infections on the Fetus and Newborn
  • Conclusion
  • References
  • Chapter 14 COVID-19 in Children and Adolescents
  • Outline
  • Coronavirus Infections in Children and Adolescents
  • Epidemiology of SARS-CoV-2 Infection in Children and Adolescents
  • Clinical Manifestations of SARS-CoV-2 Infection in Infants and Children
  • Treatment of Acute COVID-19 in Children
  • Prevention of SARS-CoV-2 Infection
  • COVID-19 Impact on Well-Being of Children
  • Conclusion
  • References
  • Part IV Special Topics: Emergency Medicine, Therapeutics, Novel Targets, Vaccines
  • Chapter 15 COVID-19: Emergency Medicine Perspectives
  • Outline
  • Introduction
  • Clinical Manifestations
  • Diagnostic Workup and Investigation
  • Management
  • Disposition
  • Special Considerations
  • Conclusion
  • References
  • Chapter 16 Therapeutics for COVID-19
  • Outline
  • Evolution of Therapeutic Approaches
  • Treatments Authorized for Emergency Use
  • Repurposed Drugs and New Molecular Entities in Clinical Development
  • Therapeutic Management: Current Guidelines and Unmet Needs
  • Conclusion
  • References
  • Chapter 17 Novel Therapeutic Targets for SARS-CoV-2 and COVID-19
  • Outline
  • Factors That Affect Therapy for Treatment of COVID-19
  • Emerging Therapeutic Treatments of the Disease
  • Brief Description of Structure and Parts of SARS-CoV-2
  • Therapeutic Targets for the Treatment of COVID-19
  • Overview of Therapies Based on Repurpose Drugs and Corresponding Targets
  • Viral Mutations and Selection of Drug Targets
  • Conclusion
  • References
  • Chapter 18 Vaccine Basics and the Development and Rollout of COVID-19 Vaccines
  • Outline
  • Historical Introduction to Vaccines
  • Vaccines and Vaccinology
  • COVID-19 Vaccine Development
  • COVID-19 Vaccine Rollout
  • Conclusion
  • References
  • Glossary
  • Acronyms
  • Index