PART I: Clinical Evaluation
1. General Aspects of the Patient’s Neurologic History
2. Neurologic Examination of the Older Child
3. Neurologic Examination of Young Children (Ages 1–5 Years)
4. Neurologic Examination of Infants (Ages 0–1 Year)
5. Motor Signs
6. Vision Loss
7. Hearing Impairment
8. Vertigo
9. Taste and Smell
10. Neuropsychological Assessment
PART II: Care of the Child With Neurologic Disorders
11. Counseling Children With Neurologic Disorders and Their Families
12. Pediatric Neurorehabilitation Medicine
13. Pediatric Palliative Care, Pain, and Symptom Management
14. Practical Bioethics in Child Neurology
15. Transitional Care for Children With Neurologic Disorders
16. Practice Guidelines in Pediatric Neurology
17. Measurement of Health Outcomes in Pediatric Neurologic Disorders
18. Computer Resources, Artificial Intelligence, and Telemedicine
19. Education and Training of Child Neurologists and Workforce Issues
PART III: Neurodiagnostic Testing
20. Cerebrospinal Fluid Examination
21. Pediatric Neuroimaging
22. Pediatric Neurophysiologic Evaluation
PART IV: Global Child Neurology
23. Regional and Global Implications for Children’s Brain Health
24. Implementing Child Neurology Care in Resource-Limited Settings
25. Adaptation and Implementation of Guidelines at the Local Level
PART V: Neonatal Neurology
26. Neonatal Neuro-Intensive Care
27. Provoked Neonatal Seizures and Neonatal Onset Epilepsy
28. Hypoxic-Ischemic Brain Injury in the Term Newborn
29. Cerebrovascular Disorders in the Newborn
30. Neonatal Nervous System Trauma
31. Injury to the Developing Preterm Brain: Intraventricular Hemorrhage and White Matter Injury
32. Perinatal Metabolic Encephalopathies
PART VI: Environment and Brain Development
33. The Neural Exposome and Environmental Neuroscience
34. Adverse Childhood Experiences
35. The Neurological Impact of Prenatal Substance Exposure
36. Environmental Pollutants
37. Malnutrition, Nutrition, and Dietary Toxins
38. Poisoning and Drug-Induced Neurologic Diseases
PART VII: Congenital Structural Defects
39. Introduction to Human Brain Malformations
40. Disorders of Neural Tube Development
41. Disorders of Forebrain Development
42. Disorders of Cerebellar and Brainstem Development
43. Microcephaly and Megalencephaly: Disorders of Brain Size
44. Malformations of Cortical Development
45. Hydrocephalus, Cysts, and Cystic Malformations
46. Congenital Anomalies of the Skull
47. Prenatal Diagnosis of Structural Brain Anomalies
PART VIII: Neurogenetics
48. Neurogenetics in the Genome Era
49. Genetic Counseling in the Genomic Era
50. Chromosomes and Chromosomal Abnormalities
51. Single-Gene Abnormalities
52. Neurocutaneous Disorders
53. Emerging Gene-Based Pathways: Channelopathies (Epilepsy and Beyond)
54. Emerging Gene-Based Pathways: mTORopathies
55. Emerging Gene-Based Pathways: RASopathies
56. Emerging Gene-Based Pathways: Chromatin Remodeling Disorders
57. The Neuronal Ceroid Lipofuscinoses
PART IX: Metabolic Disorders
58. Approach to the Patient With a Metabolic Disorder
59. Aminoacidemias and Organic Acidemias
60. Urea Cycle Disorders
61. Diseases Associated With Primary Abnormalities in Carbohydrate Metabolism
62. Disorders of Glycosylation
63. Lysosomal Storage Diseases
64. Mitochondrial Diseases
65. Peroxisomal Disorders
66. Neurotransmitter-Related Disorders
67. Disorders of Vitamin Metabolism
PART X: Neurodevelopmental Disorders
68. Neurodevelopmental Disabilities: Conceptual Framework
69. Intellectual Developmental Disorder and Global Developmental Delay
70. Regressive and Degenerative Genetic Neurological Disorders
71. Developmental Encephalopathies
72. Developmental Language Disorders
73. Nonverbal Learning Disorders
74. Dyslexia
75. Attention-Deficit/Hyperactivity Disorder
76. Autism Spectrum Disorder
77. Cerebral Palsy
78. Developmental Coordination Disorder
79. Treatment of Neurodevelopmental Disorders
80. Neuropsychopharmacology
PART XI: Epilepsy
81. Overview of Seizures and Epilepsy in Children
82. Principles of Management and Outcome
83. Pathophysiology of Seizures and Epilepsy
84. Epilepsy Genetics
85. Febrile Seizures
86. Generalized Seizures
87. Focal and Multifocal Seizures
88. Myoclonic Seizures
89. Infantile Epileptic Spasms Syndrome
90. Status Epilepticus
91. Electroclinical Syndromes: Neonatal Onset
92. Electroclinical Syndromes: Infantile Onset
93. Electroclinical Syndromes: Childhood Onset
94. Electroclinical Syndromes: Adolescent Onset
95. Focal Structural Epilepsy
96. Acquired Epilepsies: Trauma, Stroke, and Tumors
97. Inherited Metabolic Epilepsies
98. Antiseizure Medication Therapy in Children
99. Epilepsy Surgery in the Pediatric Population
100. Neuromodulation in Epilepsy
101. Ketogenic Diets
102. Behavioral, Cognitive, and Social Implications of Childhood Epilepsy
103. Mortality in Children With Epilepsy
PART XII: Nonepileptiform Paroxysmal Disorders
104. Headache in Children and Adolescents
105. Breath-Holding Spells and Reflex Anoxic Seizures
106. Psychogenic Nonepileptic Seizures and Psychiatric Disorders
107. Functional Neurological Symptom Disorder in Children and Adolescents
108. Syncope and Postural Orthostatic Tachycardia Syndrome
109. Brief Resolved Unexplained Events, Apparent Life-Threatening Events, and Sudden Infant Death Syndrome
PART XIII: Disorders of Sleep
110. Restless Legs Syndrome and Periodic Limb Movement Disorder in Children and Adolescents
111. Nocturnal Paroxysmal Disorders
112. Disorders of Excessive Sleepiness
PART XIV: Disorders of Balance and Movement
113. The Cerebellum and the Hereditary Ataxias
114. Movement Disorders: An Overview
115. Paroxysmal Dyskinesias
116. Movement Disorders of Infancy
117. Drug-Induced Movement Disorders in Children
118. Tics and Tourette Syndrome
PART XV: White Matter Disorders
119. Genetic and Metabolic Disorders of the White Matter
120. Acquired Disorders Affecting the White Matter
PART XVI: Brain Injury and Disorders of Consciousness
121. Impairment of Consciousness and Coma
122. Traumatic Brain Injury in Children
123. Abusive Head Trauma
124. Hypoxic-Ischemic Encephalopathy in Infants and Older Children
125. Disorders of Intracranial Pressure
126. Spinal Cord Injury
127. Determination of Brain Death/Death by Neurologic Criteria in Infants and Children
PART XVII: Cerebrovascular Disease in Children
128. Arterial Ischemic Stroke in Infants and Children
129. Sinovenous Thrombosis
130. Vascular Malformations, Intracerebral Hemorrhage, and Subarachnoid Hemorrhage in Infants and Children
131. Cerebral Arteriopathies
132. Coagulation Disorders and Cerebrovascular Disease in Children
PART XVIII: Infections of the Nervous System
133. Bacterial Infections of the Nervous System
134. Viral Infections of the Nervous System
135. Fungal, Rickettsial, and Parasitic Diseases of the Nervous System
136. Neurologic Complications of Immunization
PART XIX: Immune-Mediated Disorders of the Nervous System
137. Diagnosis and Management of Pediatric Neuroimmunological Disorders
138. Autoimmune Encephalitis
139. Autoimmune-Associated Epilepsies
140. Sydenham Chorea, Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcus, and Pediatric Acute Neuropsychiatric Syndrome
141. Immune-Mediated Cerebellar Disorders
142. Neurorheumatology
PART XX: Pediatric Neuro-Oncology
143. Pediatric Neuro-Oncology: An Overview
144. Medulloblastoma
145. Other Embryonal and Pineal Malignancies of the Central Nervous System
146. Ependymoma
147. Pediatric-Type Diffuse High-Grade Glioma
148. Pediatric Low-Grade Glioma
149. Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma
150. Atypical Teratoid/Rhabdoid Tumors
151. Central Nervous System Germ Cell Tumors
152. Craniopharyngiomas, Meningiomas, and Schwannomas
153. Pediatric Intradural Spinal Cord Tumors
154. Systemic Cancers and Central Nervous System Involvement
155. Treatment-Related Neurologic Sequelae of Pediatric Central Nervous System Tumors
PART XXI: Neuromuscular Disorders
156. Muscle and Nerve Development in Health and Disease
157. Diagnostic Testing in Children With Suspected Neuromuscular Disorders
158. Clinical Assessment of Pediatric Neuromuscular Disorders
159. The Floppy Infant
160. Classic Proximal Spinal Muscular Atrophy
161. Other Motor Neuron Diseases of Childhood
162. Genetic Peripheral Neuropathies
163. Acquired Peripheral Neuropathies
164. Inflammatory Neuropathies
165. Congenital Myasthenic Syndromes
166. Acquired Disorders of the Neuromuscular Junction
167. Duchenne and Becker Muscular Dystrophy
168. Congenital, Limb-Girdle, and Other Muscular Dystrophies
169. Congenital Myopathies
170. Metabolic Myopathies
171. Inflammatory Myopathies
172. Channelopathies: Myotonic Disorders and Periodic Paralysis
173. Multidisciplinary Management of Children With Neuromuscular Conditions
PART XXII: Systemic and Autonomic Nervous System Diseases
174. Endocrine Disorders of the Hypothalamus and Pituitary in Childhood and Adolescence
175. Disorders of the Autonomic Nervous System: Autonomic Dysfunction in Pediatric Practice
176. Disorders of Micturition and Defecation
177. Neurologic Disorders in Children With Heart Disease
178. Neurologic Disorders Associated With Renal Diseases
179. Neurologic Manifestations and Disorders Associated With Gastrointestinal Diseases
Index